Version 5.4
Homo sapiens Gene: ENPEP
Summary
InnateDB Gene IDBG-34204.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ENPEP
Gene Name glutamyl aminopeptidase (aminopeptidase A)
Synonyms APA; CD249; gp160
Species Homo sapiens
Ensembl Gene ENSG00000138792
Encoded Proteins
IDBP-34206
glutamyl aminopeptidase (aminopeptidase A)
IDBP-479794
glutamyl aminopeptidase (aminopeptidase A)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 4:110365733-110565285
Strand Forward strand
Band q25
Transcripts
ENST00000265162 ENSP00000265162
ENST00000510961
ENST00000509344 ENSP00000426265
ENST00000502711
ENST00000504100
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004177 aminopeptidase activity
GO:0008233 peptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0070006 metalloaminopeptidase activity
Biological Process
GO:0001525 angiogenesis
GO:0002003 angiotensin maturation
GO:0002005 angiotensin catabolic process in blood
GO:0003081 regulation of systemic arterial blood pressure by renin-angiotensin
GO:0006508 proteolysis
GO:0007267 cell-cell signaling
GO:0008283 cell proliferation
GO:0016477 cell migration
GO:0032835 glomerulus development
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005765 lysosomal membrane
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005903 brush border
GO:0009897 external side of plasma membrane
GO:0016324 apical plasma membrane
GO:0031410 cytoplasmic vesicle
GO:0045177 apical part of cell
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028024
View Gene Order
ENSBTAG00000008332
Not yet available
Pathways
NETPATH
REACTOME
REACT_147707
Metabolism of Angiotensinogen to Angiotensins pathway
REACT_17015
Metabolism of proteins pathway
REACT_160078
Peptide hormone metabolism pathway
KEGG
hsa04614
Renin-angiotensin system pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.435765 Hs.606668
RefSeq NM_001977
HUGO
OMIM
CCDS CCDS3691
HPRD 08848
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca