Version 5.4
Homo sapiens Gene: PMPCB
Summary
InnateDB Gene IDBG-34271.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PMPCB
Gene Name peptidase (mitochondrial processing) beta
Synonyms Beta-MPP; MPP11; MPPB; MPPP52; P-52
Species Homo sapiens
Ensembl Gene ENSG00000105819
Encoded Proteins
IDBP-34273
peptidase (mitochondrial processing) beta
IDBP-384563
peptidase (mitochondrial processing) beta
IDBP-384567
peptidase (mitochondrial processing) beta
IDBP-384569
peptidase (mitochondrial processing) beta
IDBP-384571
peptidase (mitochondrial processing) beta
IDBP-384573
peptidase (mitochondrial processing) beta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the peptidase M16 family and encodes a protein with a zinc-binding motif. This protein is located in the mitochondrial matrix and catalyzes the cleavage of the leader peptides of precursor proteins newly imported into the mitochondria, though it only functions as part of a heterodimeric complex. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:103297422-103329511
Strand Forward strand
Band q22.1
Transcripts
ENST00000249269 ENSP00000249269
ENST00000428154 ENSP00000390035
ENST00000456433 ENSP00000397884
ENST00000443722 ENSP00000402859
ENST00000444457 ENSP00000388934
ENST00000453466 ENSP00000408682
ENST00000498530
ENST00000469560
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 13 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004222 metalloendopeptidase activity
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0006626 protein targeting to mitochondrion
GO:0008152 metabolic process
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005759 mitochondrial matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029017
View Gene Order
ENSBTAG00000006876
Not yet available
Pathways
NETPATH
REACTOME
REACT_118595
Mitochondrial protein import pathway
REACT_17015
Metabolism of proteins pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.184211
RefSeq NM_004279
HUGO
OMIM
CCDS CCDS5730
HPRD 07539
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca