Version 5.4
Homo sapiens Gene: ZHX2
Summary
InnateDB Gene IDBG-34396.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZHX2
Gene Name zinc fingers and homeoboxes 2
Synonyms AFR1; RAF
Species Homo sapiens
Ensembl Gene ENSG00000178764
Encoded Proteins
IDBP-34398
zinc fingers and homeoboxes 2
IDBP-589912
zinc fingers and homeoboxes 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 2 of this gene family. In addition to forming homodimers, this protein heterodimerizes with member 1 of the zinc fingers and homeoboxes family. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:122781394-122974512
Strand Forward strand
Band q24.13
Transcripts
ENST00000314393 ENSP00000314709
ENST00000534247 ENSP00000452720
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
GO:0043565 sequence-specific DNA binding
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006402 mRNA catabolic process
GO:0035019 somatic stem cell maintenance
GO:0045665 negative regulation of neuron differentiation
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000071757
View Gene Order
ENSBTAG00000026309
Not yet available
Cross-References
SwissProt
TrEMBL H0YKA3
UniProt Splice Variant
Entrez Gene 22882
UniGene Hs.377090 Hs.742271
RefSeq NM_014943 XM_005250836 XM_005250837
HUGO HGNC:18513
OMIM 609185
CCDS CCDS6336
HPRD 16458
IMGT
EMBL AC016405 AC104316
GenPept
RNA Seq Atlas 22882

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca