Version 5.4
Homo sapiens Gene: KRT2
Summary
InnateDB Gene IDBG-34857.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KRT2
Gene Name keratin 2
Synonyms CK-2e; K2e; KRT2A; KRT2E; KRTE
Species Homo sapiens
Ensembl Gene ENSG00000172867
Encoded Proteins
IDBP-34859
keratin 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is expressed largely in the upper spinous layer of epidermal keratinocytes and mutations in this gene have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:52644558-52652164
Strand Reverse strand
Band q13.13
Transcripts
ENST00000309680 ENSP00000310861
ENST00000547106
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 39 [view]
Protein-Protein 39 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0005200 structural constituent of cytoskeleton
Biological Process
GO:0008544 epidermis development
GO:0031424 keratinization
GO:0032980 keratinocyte activation
GO:0043616 keratinocyte proliferation
GO:0051546 keratinocyte migration
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005882 intermediate filament
GO:0016020 membrane
GO:0045095 keratin filament
GO:0045111 intermediate filament cytoskeleton
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000064201
View Gene Order
ENSBTAG00000039261
Not yet available
Cross-References
SwissProt P35908
TrEMBL
UniProt Splice Variant
Entrez Gene 3849
UniGene Hs.707
RefSeq NM_000423
HUGO HGNC:6439
OMIM 600194
CCDS CCDS8835
HPRD
IMGT
EMBL AC055715 AC055716 AF019084 BC096294 BC099643 BC099644 M99061
GenPept AAB81946 AAC83410 AAH96294 AAH99643 AAH99644
RNA Seq Atlas 3849

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca