InnateDB Gene
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IDBG-35007.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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KRT3
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Gene Name
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keratin 3
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Synonyms
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CK3; K3
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Species
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Homo sapiens
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Ensembl Gene
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ENSG00000186442
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Encoded Proteins
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Protein Structure
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Useful resources
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Stemformatics
EHFPI
ImmGen
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Summary |
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the corneal epithelium with family member KRT12 and mutations in these genes have been associated with Meesmann's Corneal Dystrophy. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the corneal epithelium with family member KRT12 and mutations in these genes have been associated with Meesmann\'s Corneal Dystrophy. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]
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Type |
Protein coding
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Genomic Location
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Chromosome 12:52789685-52796117
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Strand
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Reverse strand
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Band
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q13.13
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Transcripts
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Number of Interactions
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This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
14
[view]
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Protein-Protein |
14
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0005198
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structural molecule activity
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Biological Process |
GO:0030855
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epithelial cell differentiation
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GO:0045104
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intermediate filament cytoskeleton organization
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Cellular Component |
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No orthologs found for this gene |
SwissProt
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P12035
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TrEMBL
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J3QST3
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UniProt Splice Variant
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Entrez Gene
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3850
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UniGene
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Hs.680652
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RefSeq
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NM_057088
XM_005268859
XM_006719392
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HUGO
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HGNC:6440
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OMIM
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148043
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CCDS
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CCDS44895
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HPRD |
01013
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IMGT
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EMBL
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AC107016
AJ628418
X05418
X05419
X05420
X05421
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GenPept
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CAA28991
CAA28992
CAA28993
CAA28994
CAA28995
CAA28996
CAF31522
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RNA Seq Atlas
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3850
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