Version 5.4
Homo sapiens Gene: KRT3
Summary
InnateDB Gene IDBG-35007.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KRT3
Gene Name keratin 3
Synonyms CK3; K3
Species Homo sapiens
Ensembl Gene ENSG00000186442
Encoded Proteins
IDBP-375685
keratin 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the corneal epithelium with family member KRT12 and mutations in these genes have been associated with Meesmann's Corneal Dystrophy. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the corneal epithelium with family member KRT12 and mutations in these genes have been associated with Meesmann\'s Corneal Dystrophy. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:52789685-52796117
Strand Reverse strand
Band q13.13
Transcripts
ENST00000417996 ENSP00000413479
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
Experimentally validated
Total 14 [view]
Protein-Protein 14 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
Biological Process
GO:0030855 epithelial cell differentiation
GO:0045104 intermediate filament cytoskeleton organization
Cellular Component
GO:0005882 intermediate filament
GO:0045095 keratin filament
Orthologs
No orthologs found for this gene
Cross-References
SwissProt P12035
TrEMBL J3QST3
UniProt Splice Variant
Entrez Gene 3850
UniGene Hs.680652
RefSeq NM_057088 XM_005268859 XM_006719392
HUGO HGNC:6440
OMIM 148043
CCDS CCDS44895
HPRD 01013
IMGT
EMBL AC107016 AJ628418 X05418 X05419 X05420 X05421
GenPept CAA28991 CAA28992 CAA28993 CAA28994 CAA28995 CAA28996 CAF31522
RNA Seq Atlas 3850

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca