Version 5.4
Homo sapiens Gene: KRT78
Summary
InnateDB Gene IDBG-35157.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KRT78
Gene Name keratin 78
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000170423
Encoded Proteins
IDBP-35159
keratin 78
IDBP-35161
keratin 78
IDBP-588770
keratin 78
IDBP-587366
keratin 78
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the type II keratin gene family and encodes a protein with an intermediate filament domain. Keratins are the major structural proteins in epithelial cells, forming a cytoplasmic network of 10 to 12 nm wide intermediate filaments and creating a scaffold that gives cells the ability to withstand mechanical and non-mechanical stresses. The genes of the type II keratin family are located as a gene cluster at 12p13.13. Four pseudogenes of this gene family have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:52837804-52849092
Strand Reverse strand
Band q13.13
Transcripts
ENST00000359499 ENSP00000352479
ENST00000304620 ENSP00000306261
ENST00000547920 ENSP00000448562
ENST00000547110 ENSP00000447817
ENST00000551581
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
Biological Process
Cellular Component
GO:0005615 extracellular space
GO:0005882 intermediate filament
GO:0045095 keratin filament
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000050463
View Gene Order
ENSBTAG00000039967
Not yet available
Cross-References
SwissProt Q8N1N4
TrEMBL B4DQ49 F8VS93
UniProt Splice Variant
Entrez Gene 196374
UniGene Hs.665267
RefSeq NM_001300814 NM_173352 XM_005268695
HUGO HGNC:28926
OMIM 611159
CCDS CCDS73473 CCDS8840
HPRD
IMGT
EMBL AC107016 AK096419 AK290901 AK298636 BK000646 BX647095 CH471054
GenPept BAC04782 BAF83590 BAG60811 CAI46001 DAA00377 EAW96650
RNA Seq Atlas 196374

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca