Homo sapiens Gene: AP1M1

Summary
InnateDB Gene IDBG-35433.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol AP1M1
Gene Name adaptor-related protein complex 1, mu 1 subunit
Synonyms AP47; CLAPM2; CLTNM; MU-1A
Species Homo sapiens
Ensembl Gene ENSG00000072958
Encoded Proteins
IDBP-35435 adaptor-related protein complex 1, mu 1 subunit
IDBP-374847 adaptor-related protein complex 1, mu 1 subunit
IDBP-374850 adaptor-related protein complex 1, mu 1 subunit
IDBP-595488 adaptor-related protein complex 1, mu 1 subunit
IDBP-762301
IDBP-762612
IDBP-765340
IDBP-766105
IDBP-764976
IDBP-764042
Entrez Gene
Summary The protein encoded by this gene is the medium chain of the trans-Golgi network clathrin-associated protein complex AP-1. The other components of this complex are beta-prime-adaptin, gamma-adaptin, and the small chain AP1S1. This complex is located at the Golgi vesicle and links clathrin to receptors in coated vesicles. These vesicles are involved in endocytosis and Golgi processing. Alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19: 16308389-16346160
Strand Forward strand
Band p13.11
Transcripts
ENST00000291439  ENSP00000291439
ENST00000444449  ENSP00000388996
ENST00000429941  ENSP00000411498
ENST00000541844  ENSP00000445682
ENST00000586957 
ENST00000590756  ENSP00000465224
ENST00000592703 
ENST00000590263  ENSP00000466858
ENST00000591966 
ENST00000590945  ENSP00000467721
ENST00000589822  ENSP00000468140
ENST00000586543  ENSP00000468015
ENST00000591775  ENSP00000467417
ENST00000589782 
ENST00000586461 
ENST00000589991 
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 36 [view]
Protein‑Protein  35
[view]
Protein‑DNA 1
[view]
Protein‑RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
 
Predicted by orthology
Total [view]
Gene Ontology
Accession GO Term
Molecular Function
GO:0005515 protein binding
Biological Process
GO:0006810 transport
GO:0006886 intracellular protein transport
GO:0006892 post-Golgi vesicle-mediated transport
GO:0016032 viral reproduction
GO:0016044 cellular membrane organization
GO:0016192 vesicle-mediated transport
GO:0019048 virus-host interaction
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0032438 melanosome organization
GO:0035646 endosome to melanosome transport
GO:0050690 regulation of defense response to virus by virus
Cellular Component
GO:0000139 Golgi membrane
GO:0005765 lysosomal membrane
GO:0005829 cytosol
GO:0030131 clathrin adaptor complex
GO:0030659 cytoplasmic vesicle membrane
GO:0030665 clathrin-coated vesicle membrane
GO:0032588 trans-Golgi network membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID Gene Order Method Confidence Comments
ENSMUSG00000003033 Ortholuge SSD Ortholog Ortholog supports species divergence
ENSBTAG00000013329 Not yet available Ortholuge SSD Ortholog Ortholog supports species divergence
Pathways
NETPATH
REACTOME
REACT_19400 Golgi Associated Vesicle Biogenesis
REACT_19287 Lysosome Vesicle Biogenesis
REACT_121399 MHC class II antigen presentation
REACT_11103 Nef mediated downregulation of MHC class I complex cell surface expression
KEGG
hsa04142  Lysosome
INOH
PID BIOCARTA
PID NCI
ecadherin_nascentaj_pathway E-cadherin signaling in the nascent adherens junction
Cross-References
SwissProt Q9BXS5 
TrEMBL B4DDG7 E7ENJ6 Q59EK3
UniProt Splice Variant
Entrez Gene 8907 
UniGene Hs.619927 Hs.71040
RefSeq NM_001130524  NM_032493 
HUGO 13667 
OMIM 603535
CCDS CCDS12342  CCDS46008 
HPRD 04639
IMGT
EMBL AB209808 AC020911 AF290613 AK293188 BC017469 DQ059565
GenPept AAH17469  AAK28024  AAY54246  BAD93045  BAG56728 
ImmGen AP1M1 (murine) 
RNA Seq Atlas 8907