Homo sapiens Gene: AP1M1
Summary
InnateDB Gene IDBG-35433.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AP1M1
Gene Name adaptor-related protein complex 1, mu 1 subunit
Synonyms AP47; CLAPM2; CLTNM; MU-1A;
Species Homo sapiens
Ensembl Gene ENSG00000072958
Encoded Proteins
adaptor-related protein complex 1, mu 1 subunit
adaptor-related protein complex 1, mu 1 subunit
adaptor-related protein complex 1, mu 1 subunit
adaptor-related protein complex 1, mu 1 subunit
Protein Structure
Entrez Gene
Summary The protein encoded by this gene is the medium chain of the trans-Golgi network clathrin-associated protein complex AP-1. The other components of this complex are beta-prime-adaptin, gamma-adaptin, and the small chain AP1S1. This complex is located at the Golgi vesicle and links clathrin to receptors in coated vesicles. These vesicles are involved in endocytosis and Golgi processing. Alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:16197578-16245907
Strand Forward strand
Band p13.11
Transcripts
ENST00000291439 ENSP00000291439
ENST00000444449 ENSP00000388996
ENST00000429941 ENSP00000411498
ENST00000586957
ENST00000590756 ENSP00000465224
ENST00000592703
ENST00000590263 ENSP00000466858
ENST00000591966
ENST00000590945 ENSP00000467721
ENST00000589822 ENSP00000468140
ENST00000586543 ENSP00000468015
ENST00000591775 ENSP00000467417
ENST00000589782 ENSP00000482949
ENST00000586461
ENST00000589991
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 32 [view]
Protein-Protein 31 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006810 transport
GO:0006886 intracellular protein transport
GO:0006892 post-Golgi vesicle-mediated transport
GO:0015031 protein transport
GO:0016032 viral process
GO:0016192 vesicle-mediated transport
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0032438 melanosome organization
GO:0035646 endosome to melanosome transport
GO:0050690 regulation of defense response to virus by virus
GO:0061024 membrane organization
Cellular Component
GO:0000139 Golgi membrane
GO:0005765 lysosomal membrane
GO:0005829 cytosol
GO:0016020 membrane
GO:0030131 clathrin adaptor complex
GO:0030659 cytoplasmic vesicle membrane
GO:0030665 clathrin-coated vesicle membrane
GO:0032588 trans-Golgi network membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
MHC class II antigen presentation pathway
trans-Golgi Network Vesicle Budding pathway
Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters pathway
Adaptive Immune System pathway
Clathrin derived vesicle budding pathway
Immune System pathway
Golgi Associated Vesicle Biogenesis pathway
HIV Infection pathway
Lysosome Vesicle Biogenesis pathway
Nef mediated downregulation of MHC class I complex cell surface expression pathway
The role of Nef in HIV-1 replication and disease pathogenesis pathway
Host Interactions of HIV factors pathway
Disease pathway
Membrane Trafficking pathway
KEGG
Lysosome pathway
INOH
PID BIOCARTA
PID NCI
E-cadherin signaling in the nascent adherens junction
Cross-References
SwissProt Q9BXS5
TrEMBL A0A024R7K8 E7ENJ6 K7EJL1 K7ENA7 K7EPJ8 K7EQ90 K7ER75 Q59EK3
UniProt Splice Variant
Entrez Gene 8907
UniGene Hs.619927 Hs.71040
RefSeq NM_001130524 NM_032493
HUGO HGNC:13667
OMIM 603535
CCDS CCDS12342 CCDS46008
HPRD 04639
IMGT
EMBL AB209808 AC020911 AF290613 BC017469 CH471106 DQ059565
GenPept AAH17469 AAK28024 AAY54246 BAD93045 EAW84539 EAW84540
ImmGen AP1M1 (murine)
RNA Seq Atlas 8907