Version 5.4
Homo sapiens Gene: SLC26A4
Summary
InnateDB Gene IDBG-35677.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC26A4
Gene Name solute carrier family 26, member 4
Synonyms DFNB4; EVA; PDS; TDH2B
Species Homo sapiens
Ensembl Gene ENSG00000091137
Encoded Proteins
IDBP-35679
solute carrier family 26, member 4
IDBP-385014
solute carrier family 26, member 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Mutations in this gene are associated with Pendred syndrome, the most common form of syndromic deafness, an autosomal-recessive disease. It is highly homologous to the SLC26A3 gene; they have similar genomic structures and this gene is located 3' of the SLC26A3 gene. The encoded protein has homology to sulfate transporters. [provided by RefSeq, Jul 2008]
Mutations in this gene are associated with Pendred syndrome, the most common form of syndromic deafness, an autosomal-recessive disease. It is highly homologous to the SLC26A3 gene; they have similar genomic structures and this gene is located 3\' of the SLC26A3 gene. The encoded protein has homology to sulfate transporters. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:107660635-107717809
Strand Forward strand
Band q22.3
Transcripts
ENST00000265715 ENSP00000265715
ENST00000440056 ENSP00000394760
ENST00000477350
ENST00000497446
ENST00000480841
ENST00000460748
ENST00000492030
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 0
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008271 secondary active sulfate transmembrane transporter activity
GO:0015108 chloride transmembrane transporter activity
GO:0015111 iodide transmembrane transporter activity
GO:0015116 sulfate transmembrane transporter activity
Biological Process
GO:0006811 ion transport
GO:0006821 chloride transport
GO:0006885 regulation of pH
GO:0007605 sensory perception of sound
GO:0008272 sulfate transport
GO:0015698 inorganic anion transport
GO:0015705 iodide transport
GO:0032880 regulation of protein localization
GO:0055085 transmembrane transport
GO:1902358 sulfate transmembrane transport
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0031526 brush border membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020651
View Gene Order
ENSBTAG00000010062
Not yet available
Pathways
NETPATH
REACTOME
REACT_19357
Multifunctional anion exchangers pathway
REACT_19397
Transport of inorganic cations/anions and amino acids/oligopeptides pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_19118
SLC-mediated transmembrane transport pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL C9JQG1
UniProt Splice Variant
Entrez Gene 5172
UniGene Hs.571246
RefSeq NM_000441 XM_005250425 XM_006716024
HUGO HGNC:8818
OMIM 605646
CCDS CCDS5746
HPRD 05735
IMGT
EMBL AC002467 AC078937
GenPept
RNA Seq Atlas 5172

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca