InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MED26

Summary

InnateDB Gene

IDBG-35738.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MED26

Gene Name

mediator complex subunit 26

Synonyms

CRSP7; CRSP70

Species

Homo sapiens

Ensembl Gene

ENSG00000105085

Encoded Proteins

IDBP-35740

mediator complex subunit 26

IDBP-765807

IDBP-763942

IDBP-761860

IDBP-764171

IDBP-812287

mediator complex subunit 26

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:16574907-16629062

Strand

Reverse strand

Band

p13.11

Transcripts

ENST00000263390	ENSP00000263390
ENST00000598608	ENSP00000471040
ENST00000600060	ENSP00000472880
ENST00000598492	ENSP00000469434
ENST00000597244
ENST00000601478	ENSP00000472706
ENST00000611692	ENSP00000484490

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 102 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	102 [view]
Protein-Protein	100 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001104	RNA polymerase II transcription cofactor activity
GO:0003677	DNA binding
GO:0003713	transcription coactivator activity
GO:0005515	protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0010467	gene expression