InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SLC26A3

Summary

InnateDB Gene

IDBG-35753.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC26A3

Gene Name

solute carrier family 26, member 3

Synonyms

CLD; DRA

Species

Homo sapiens

Ensembl Gene

ENSG00000091138

Encoded Proteins

IDBP-35755

solute carrier family 26, member 3

IDBP-35757

solute carrier family 26, member 3

IDBP-385049

solute carrier family 26, member 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a transmembrane glycoprotein that transports chloride ions across the cell membrane in exchange for bicarbonate ions. It is localized to the mucosa of the lower intestinal tract, particularly to the apical membrane of columnar epithelium and some goblet cells. The protein is essential for intestinal chloride absorption, and mutations in this gene have been associated with congenital chloride diarrhea. [provided by RefSeq, Oct 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:107765467-107803225

Strand

Reverse strand

Band

q31.1

Transcripts

ENST00000340010	ENSP00000345873
ENST00000379083	ENSP00000368375
ENST00000453332	ENSP00000395955
ENST00000469651
ENST00000468551

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003712	transcription cofactor activity
GO:0005215	transporter activity
GO:0005515	protein binding
GO:0008271	secondary active sulfate transmembrane transporter activity
GO:0015106	bicarbonate transmembrane transporter activity
GO:0015108	chloride transmembrane transporter activity
GO:0015116	sulfate transmembrane transporter activity
GO:0015301	anion:anion antiporter activity

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006811	ion transport
GO:0006820	anion transport
GO:0006821	chloride transport
GO:0007588	excretion
GO:0008272	sulfate transport
GO:0015701	bicarbonate transport
GO:0048240	sperm capacitation
GO:0051454	intracellular pH elevation
GO:0055085	transmembrane transport
GO:0060081	membrane hyperpolarization
GO:0071320	cellular response to cAMP
GO:1902358	sulfate transmembrane transport
GO:1902476	chloride transmembrane transport
GO:2001141	regulation of RNA biosynthetic process

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0031526	brush border membrane
GO:0097225	sperm midpiece

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000001225

View Gene Order

ENSBTAG00000015547

Not yet available

Pathways

NETPATH

REACTOME

REACT_19357

Multifunctional anion exchangers pathway

REACT_19397

Transport of inorganic cations/anions and amino acids/oligopeptides pathway

REACT_15518

Transmembrane transport of small molecules pathway

REACT_19118

SLC-mediated transmembrane transport pathway

KEGG

hsa04972

Pancreatic secretion pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.1650

RefSeq

NM_000111 XM_006715873

HUGO

OMIM

CCDS

CCDS5748

HPRD

00544

IMGT

EMBL

GenPept

RNA Seq Atlas