Version 5.4
Homo sapiens Gene: CSAD
Summary
InnateDB Gene IDBG-35859.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CSAD
Gene Name cysteine sulfinic acid decarboxylase
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000139631
Encoded Proteins
IDBP-35861
cysteine sulfinic acid decarboxylase
IDBP-35863
cysteine sulfinic acid decarboxylase
IDBP-35869
cysteine sulfinic acid decarboxylase
IDBP-35871
cysteine sulfinic acid decarboxylase
IDBP-376105
cysteine sulfinic acid decarboxylase
IDBP-376120
cysteine sulfinic acid decarboxylase
IDBP-376128
cysteine sulfinic acid decarboxylase
IDBP-376134
cysteine sulfinic acid decarboxylase
IDBP-376137
cysteine sulfinic acid decarboxylase
IDBP-598400
cysteine sulfinic acid decarboxylase
IDBP-716837
IDBP-718396
IDBP-599590
cysteine sulfinic acid decarboxylase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the group 2 decarboxylase family. A similar protein in rodents plays a role in multiple biological processes as the rate-limiting enzyme in taurine biosynthesis, catalyzing the decarboxylation of cysteinesulfinate to hypotaurine. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:53157663-53180909
Strand Reverse strand
Band q13.13
Transcripts
ENST00000267085 ENSP00000267085
ENST00000379850 ENSP00000369179
ENST00000379846 ENSP00000369175
ENST00000379843 ENSP00000369172
ENST00000453446 ENSP00000410648
ENST00000444623 ENSP00000415485
ENST00000424845 ENSP00000390269
ENST00000454442
ENST00000437073 ENSP00000415314
ENST00000424990 ENSP00000401078
ENST00000475890 ENSP00000436800
ENST00000490923
ENST00000490589
ENST00000485004
ENST00000483632 ENSP00000455618
ENST00000472908
ENST00000491654
ENST00000498635 ENSP00000457264
ENST00000461392
ENST00000548698 ENSP00000449373
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
Experimentally validated
Total 20 [view]
Protein-Protein 20 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004782 sulfinoalanine decarboxylase activity
GO:0016829 lyase activity
GO:0016831 carboxy-lyase activity
GO:0030170 pyridoxal phosphate binding
Biological Process
GO:0000096 sulfur amino acid metabolic process
GO:0000098 sulfur amino acid catabolic process
GO:0006520 cellular amino acid metabolic process
GO:0008152 metabolic process
GO:0019752 carboxylic acid metabolic process
GO:0034641 cellular nitrogen compound metabolic process
GO:0042412 taurine biosynthetic process
GO:0044281 small molecule metabolic process
Cellular Component
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000023044
View Gene Order
ENSBTAG00000007829
Not yet available
Pathways
NETPATH
REACTOME
REACT_115654
Degradation of cysteine and homocysteine pathway
REACT_115639
Sulfur amino acid metabolism pathway
REACT_13
Metabolism of amino acids and derivatives pathway
REACT_111217
Metabolism pathway
KEGG
hsa00430
Taurine and hypotaurine metabolism pathway
INOH
INOH website
Methionine Cysteine metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.279815
RefSeq NM_001244705 NM_001244706 NM_015989 XM_005268954 XM_006719447
HUGO
OMIM
CCDS CCDS58235 CCDS8848
HPRD 16763
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca