Version 5.4
Homo sapiens Gene: HSF4
Summary
InnateDB Gene IDBG-36097.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HSF4
Gene Name heat shock transcription factor 4
Synonyms CTM; CTRCT5
Species Homo sapiens
Ensembl Gene ENSG00000102878
Encoded Proteins
IDBP-36099
heat shock transcription factor 4
IDBP-378874
heat shock transcription factor 4
IDBP-809070
IDBP-477069
heat shock transcription factor 4
IDBP-484576
heat shock transcription factor 4
IDBP-482739
heat shock transcription factor 4
IDBP-474401
heat shock transcription factor 4
IDBP-481468
heat shock transcription factor 4
IDBP-476349
heat shock transcription factor 4
IDBP-475853
heat shock transcription factor 4
IDBP-477868
heat shock transcription factor 4
IDBP-480486
heat shock transcription factor 4
IDBP-483773
heat shock transcription factor 4
IDBP-480058
heat shock transcription factor 4
IDBP-482427
heat shock transcription factor 4
IDBP-485294
heat shock transcription factor 4
IDBP-750393
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Heat-shock transcription factors (HSFs) activate heat-shock response genes under conditions of heat or other stresses. HSF4 lacks the carboxyl-terminal hydrophobic repeat which is shared among all vertebrate HSFs and has been suggested to be involved in the negative regulation of DNA binding activity. Two alternatively spliced transcripts encoding distinct isoforms and possessing different transcriptional activity have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:67163385-67169945
Strand Forward strand
Band q22.1
Transcripts
ENST00000264009 ENSP00000264009
ENST00000434833 ENSP00000403219
ENST00000518227 ENSP00000476527
ENST00000518603
ENST00000522870
ENST00000522295 ENSP00000427832
ENST00000522023
ENST00000521314 ENSP00000429580
ENST00000521624 ENSP00000428161
ENST00000523562 ENSP00000430631
ENST00000517685 ENSP00000428978
ENST00000521374 ENSP00000430947
ENST00000523077
ENST00000517729 ENSP00000430299
ENST00000519224 ENSP00000430724
ENST00000517750 ENSP00000430211
ENST00000517680
ENST00000522027
ENST00000522459
ENST00000519105
ENST00000517867
ENST00000519601 ENSP00000428077
ENST00000520833
ENST00000520528 ENSP00000427963
ENST00000520247
ENST00000520304 ENSP00000430840
ENST00000521916 ENSP00000429486
ENST00000584272 ENSP00000463706
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
Experimentally validated
Total 28 [view]
Protein-Protein 27 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003714 transcription corepressor activity
GO:0019903 protein phosphatase binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001654 eye development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006950 response to stress
GO:0008284 positive regulation of cell proliferation
GO:0033169 histone H3-K9 demethylation
GO:0043010 camera-type eye development
GO:0045597 positive regulation of cell differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048468 cell development
GO:0070207 protein homotrimerization
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000033249
View Gene Order
ENSBTAG00000003514
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.512156
RefSeq NM_001040667 NM_001538 NM_018378
HUGO
OMIM
CCDS CCDS42175 CCDS45510 CCDS10831
HPRD 03896
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca