InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NDRG1

Summary

InnateDB Gene

IDBG-36420.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NDRG1

Gene Name

N-myc downstream regulated 1

Synonyms

CAP43; CMT4D; DRG-1; DRG1; GC4; HMSNL; NDR1; NMSL; PROXY1; RIT42; RTP; TARG1; TDD5

Species

Homo sapiens

Ensembl Gene

ENSG00000104419

Encoded Proteins

IDBP-36422

N-myc downstream regulated 1

IDBP-376664

N-myc downstream regulated 1

IDBP-484969

N-myc downstream regulated 1

IDBP-477543

N-myc downstream regulated 1

IDBP-476514

N-myc downstream regulated 1

IDBP-475279

N-myc downstream regulated 1

IDBP-477229

N-myc downstream regulated 1

IDBP-474515

N-myc downstream regulated 1

IDBP-482395

N-myc downstream regulated 1

IDBP-476507

N-myc downstream regulated 1

IDBP-475278

N-myc downstream regulated 1

IDBP-480261

N-myc downstream regulated 1

IDBP-475666

N-myc downstream regulated 1

IDBP-483807

N-myc downstream regulated 1

IDBP-483317

N-myc downstream regulated 1

IDBP-483832

N-myc downstream regulated 1

IDBP-600236

N-myc downstream regulated 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation. The encoded protein is necessary for p53-mediated caspase activation and apoptosis. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4D, and expression of this gene may be a prognostic indicator for several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:133237171-133302022

Strand

Reverse strand

Band

q24.22

Transcripts

ENST00000323851	ENSP00000319977
ENST00000414097	ENSP00000404854
ENST00000521438
ENST00000521026
ENST00000521414
ENST00000519278
ENST00000517599	ENSP00000429172
ENST00000518176	ENSP00000429007
ENST00000522476	ENSP00000427894
ENST00000518066	ENSP00000431057
ENST00000523642
ENST00000522665
ENST00000517331
ENST00000522377	ENSP00000429380
ENST00000521664
ENST00000520230	ENSP00000428345
ENST00000518010
ENST00000518480	ENSP00000428802
ENST00000519228	ENSP00000429994
ENST00000519580	ENSP00000429272
ENST00000522890	ENSP00000428384
ENST00000520943	ENSP00000429840
ENST00000521544	ENSP00000429524
ENST00000517745
ENST00000518094
ENST00000522738	ENSP00000428991
ENST00000523892	ENSP00000430171
ENST00000523931
ENST00000537882	ENSP00000437443

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 92 experimentally validated interaction(s) in this database.

Experimentally validated
Total	92 [view]
Protein-Protein	87 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0017137	Rab GTPase binding
GO:0043015	gamma-tubulin binding
GO:0045296	cadherin binding

Biological Process

GO:0008219	cell death
GO:0010038	response to metal ion
GO:0030330	DNA damage response, signal transduction by p53 class mediator
GO:0032287	peripheral nervous system myelin maintenance
GO:0045576	mast cell activation
GO:0071456	cellular response to hypoxia
GO:0090232	positive regulation of spindle checkpoint

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005829	cytosol
GO:0005874	microtubule
GO:0005886	plasma membrane
GO:0005913	cell-cell adherens junction
GO:0015630	microtubule cytoskeleton
GO:0048471	perinuclear region of cytoplasm
GO:0055038	recycling endosome membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000005125

View Gene Order

ENSBTAG00000000711

Not yet available

Pathways

NETPATH

REACTOME

KEGG

INOH

PID NCI

p53downstreampathway

Direct p53 effectors

myc_represspathway

Validated targets of C-MYC transcriptional repression

hif1_tfpathway

HIF-1-alpha transcription factor network

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.372914 Hs.613170

RefSeq

NM_001135242 NM_001258432 NM_001258433 NM_006096

HUGO

OMIM

CCDS

CCDS34945 CCDS59112 CCDS59113

HPRD

05586

IMGT

EMBL

GenPept

RNA Seq Atlas