InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: LGR4

Summary

InnateDB Gene

IDBG-36645.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LGR4

Gene Name

leucine-rich repeat containing G protein-coupled receptor 4

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000205213

Encoded Proteins

IDBP-36647

leucine-rich repeat containing G protein-coupled receptor 4

IDBP-36651

leucine-rich repeat containing G protein-coupled receptor 4

IDBP-600713

leucine-rich repeat containing G protein-coupled receptor 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 23589304

[Mus musculus] Lgr4 deletion potentiates TLR2/4-mediated cytokine production and Lgr4 null mice are more susceptible to septic shock.

Entrez Gene

Summary

G protein-coupled receptors (GPCRs) play key roles in a variety of physiologic functions. Members of the leucine-rich GPCR (LGR) family, such as GPR48, have multiple N-terminal leucine-rich repeats (LRRs) and a 7-transmembrane domain (Weng et al., 2008 [PubMed 18424556]).[supplied by OMIM, Aug 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:27365961-27472775

Strand

Reverse strand

Band

p14.1

Transcripts

ENST00000379214	ENSP00000368516
ENST00000389858	ENSP00000374508
ENST00000489910
ENST00000480977	ENSP00000431650
ENST00000530658
ENST00000527773

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 200 experimentally validated interaction(s) in this database.

Experimentally validated
Total	200 [view]
Protein-Protein	199 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding

Biological Process

GO:0001649	osteoblast differentiation
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007283	spermatogenesis
GO:0030282	bone mineralization
GO:0030539	male genitalia development
GO:0034122	negative regulation of toll-like receptor signaling pathway
GO:0035239	tube morphogenesis
GO:0045087	innate immune response
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0046849	bone remodeling
GO:0050673	epithelial cell proliferation
GO:0050710	negative regulation of cytokine secretion
GO:0061290	canonical Wnt signaling pathway involved in metanephric kidney development
GO:0072202	cell differentiation involved in metanephros development
GO:0072224	metanephric glomerulus development
GO:0072282	metanephric nephron tubule morphogenesis
GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis
GO:0090263	positive regulation of canonical Wnt signaling pathway