Version 5.4
Homo sapiens Gene: ATP5G2
Summary
InnateDB Gene IDBG-37114.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ATP5G2
Gene Name ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
Synonyms ATP5A
Species Homo sapiens
Ensembl Gene ENSG00000135390
Encoded Proteins
IDBP-37116
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
IDBP-241765
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
IDBP-592846
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
IDBP-602990
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
IDBP-595465
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
IDBP-811883
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and single representatives of the gamma, delta, and epsilon subunits. The proton channel likely has nine subunits (a, b, c, d, e, f, g, F6 and 8). There are three separate genes which encode subunit c of the proton channel and they specify precursors with different import sequences but identical mature proteins. The protein encoded by this gene is one of three precursors of subunit c. Alternatively spliced transcript variants encoding different isoforms have been identified. This gene has multiple pseudogenes. [provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:53632726-53677408
Strand Reverse strand
Band q13.13
Transcripts
ENST00000338662 ENSP00000340315
ENST00000394349 ENSP00000377878
ENST00000495596
ENST00000550241
ENST00000552242 ENSP00000448801
ENST00000549164 ENSP00000447317
ENST00000549748 ENSP00000447643
ENST00000552120
ENST00000602871 ENSP00000473535
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 4 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0008289 lipid binding
GO:0015078 hydrogen ion transmembrane transporter activity
Biological Process
GO:0015986 ATP synthesis coupled proton transport
GO:0015991 ATP hydrolysis coupled proton transport
GO:0045471 response to ethanol
Cellular Component
GO:0005753 mitochondrial proton-transporting ATP synthase complex
GO:0016021 integral component of membrane
GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain
GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o)
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000062683
View Gene Order
ENSBTAG00000005735
Not yet available
Pathways
NETPATH
REACTOME
REACT_6759
Formation of ATP by chemiosmotic coupling pathway
REACT_6305
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. pathway
REACT_111083
The citric acid (TCA) cycle and respiratory electron transport pathway
REACT_111217
Metabolism pathway
KEGG
hsa05010
Alzheimer's disease pathway
hsa00190
Oxidative phosphorylation pathway
hsa05012
Parkinson's disease pathway
hsa05016
Huntington's disease pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 517
UniGene Hs.524464
RefSeq NM_001002031 NM_005176
HUGO HGNC:842
OMIM 603193
CCDS CCDS31812 CCDS8863
HPRD 04429
IMGT
EMBL
GenPept
RNA Seq Atlas 517

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca