InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MET

Summary

InnateDB Gene

IDBG-37371.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MET

Gene Name

met proto-oncogene (hepatocyte growth factor receptor)

Synonyms

AUTS9; c-Met; HGFR; RCCP2

Species

Homo sapiens

Ensembl Gene

ENSG00000105976

Encoded Proteins

IDBP-37373

met proto-oncogene (hepatocyte growth factor receptor)

IDBP-234643

met proto-oncogene (hepatocyte growth factor receptor)

IDBP-385597

met proto-oncogene (hepatocyte growth factor receptor)

IDBP-385605

met proto-oncogene (hepatocyte growth factor receptor)

IDBP-385607

met proto-oncogene (hepatocyte growth factor receptor)

IDBP-385608

met proto-oncogene (hepatocyte growth factor receptor)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:116672390-116798386

Strand

Forward strand

Band

q31.2

Transcripts

ENST00000318493	ENSP00000317272
ENST00000397752	ENSP00000380860
ENST00000456159	ENSP00000413857
ENST00000436117	ENSP00000410980
ENST00000422097	ENSP00000398776
ENST00000454623	ENSP00000398140
ENST00000495962

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 144 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	144 [view]
Protein-Protein	138 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0004714	transmembrane receptor protein tyrosine kinase activity
GO:0004872	receptor activity
GO:0005008	hepatocyte growth factor-activated receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019903	protein phosphatase binding

Biological Process

GO:0000187	activation of MAPK activity
GO:0001889	liver development
GO:0001890	placenta development
GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0007166	cell surface receptor signaling pathway
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007275	multicellular organismal development
GO:0007411	axon guidance
GO:0007420	brain development
GO:0007517	muscle organ development
GO:0007519	skeletal muscle tissue development
GO:0008283	cell proliferation
GO:0010828	positive regulation of glucose transport
GO:0014812	muscle cell migration
GO:0014902	myotube differentiation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0030534	adult behavior
GO:0042593	glucose homeostasis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046777	protein autophosphorylation
GO:0048012	hepatocyte growth factor receptor signaling pathway
GO:0048754	branching morphogenesis of an epithelial tube
GO:0050918	positive chemotaxis
GO:0051450	myoblast proliferation
GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
GO:0071526	semaphorin-plexin signaling pathway
GO:1901299	negative regulation of hydrogen peroxide-mediated programmed cell death
GO:2001028	positive regulation of endothelial cell chemotaxis

Cellular Component

GO:0005576	extracellular region
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009925	basal plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane