Version 5.4
Homo sapiens Gene: RAB34
Summary
InnateDB Gene IDBG-37386.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RAB34
Gene Name RAB34, member RAS oncogene family
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000109113
Encoded Proteins
IDBP-37388
RAB34, member RAS oncogene family
IDBP-37390
RAB34, member RAS oncogene family
IDBP-239926
RAB34, member RAS oncogene family
IDBP-239928
RAB34, member RAS oncogene family
IDBP-239930
RAB34, member RAS oncogene family
IDBP-373928
RAB34, member RAS oncogene family
IDBP-373932
RAB34, member RAS oncogene family
IDBP-761710
IDBP-373937
RAB34, member RAS oncogene family
IDBP-373940
RAB34, member RAS oncogene family
IDBP-373944
RAB34, member RAS oncogene family
IDBP-373946
RAB34, member RAS oncogene family
IDBP-373948
RAB34, member RAS oncogene family
IDBP-764513
IDBP-811826
RAB34, member RAS oncogene family
IDBP-763045
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein belonging to the RAB family of proteins, which are small GTPases involved in protein transport. This family member is a Golgi-bound member of the secretory pathway that is involved in the repositioning of lysosomes and the activation of macropinocytosis. Alternative splicing of this gene results in multiple transcript variants. This gene overlaps and shares exon structure with the nine-amino acid residue-repeats (NARR) gene, which encodes a functionally distinct nucleolar protein from a different reading frame. [provided by RefSeq, Jan 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:28714284-28718429
Strand Reverse strand
Band q11.2
Transcripts
ENST00000301043 ENSP00000301043
ENST00000353676 ENSP00000226259
ENST00000395245 ENSP00000378666
ENST00000395243 ENSP00000378664
ENST00000395242 ENSP00000378663
ENST00000415040 ENSP00000410279
ENST00000453384 ENSP00000413156
ENST00000419712 ENSP00000464723
ENST00000450529 ENSP00000391048
ENST00000422279 ENSP00000397499
ENST00000436730 ENSP00000404180
ENST00000430132 ENSP00000407953
ENST00000412625 ENSP00000398706
ENST00000484161
ENST00000474704
ENST00000496866
ENST00000481501
ENST00000483554
ENST00000482688
ENST00000583538 ENSP00000463488
ENST00000582934 ENSP00000476427
ENST00000580843 ENSP00000465352
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0019001 guanyl nucleotide binding
Biological Process
GO:0006184 GTP catabolic process
GO:0006886 intracellular protein transport
GO:0006897 endocytosis
GO:0006913 nucleocytoplasmic transport
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0015031 protein transport
GO:0019882 antigen processing and presentation
GO:0032418 lysosome localization
GO:0043001 Golgi to plasma membrane protein transport
GO:0072659 protein localization to plasma membrane
GO:0090382 phagosome maturation
GO:0090385 phagosome-lysosome fusion
Cellular Component
GO:0001726 ruffle
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005769 early endosome
GO:0005794 Golgi apparatus
GO:0005795 Golgi stack
GO:0016020 membrane
GO:0030670 phagocytic vesicle membrane
GO:0031982 vesicle
GO:0031985 Golgi cisterna
GO:0045335 phagocytic vesicle
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000002059
View Gene Order
ENSBTAG00000046129
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.301853
RefSeq NM_001142624 NM_001142625 NM_001144942 NM_001144943 NM_001256276 NM_001256277 NM_001256278 NM_001256281 NM_031934
HUGO
OMIM
CCDS CCDS11240 CCDS45636 CCDS54101 CCDS58536
HPRD 06701
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca