Version 5.4
| Homo sapiens Gene: PIK3R2 | |||||||||||||||||||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||||||||||||||||||
| InnateDB Gene | IDBG-37719.6 | ||||||||||||||||||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||||||||||
| Gene Symbol | PIK3R2 | ||||||||||||||||||||||||||||||||||||||
| Gene Name | phosphoinositide-3-kinase, regulatory subunit 2 (beta) | ||||||||||||||||||||||||||||||||||||||
| Synonyms | |||||||||||||||||||||||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||||||||||||||||||||||
| Ensembl Gene | ENSG00000105647 | ||||||||||||||||||||||||||||||||||||||
| Encoded Proteins |
phosphoinositide-3-kinase, regulatory subunit 2 (beta)
phosphoinositide-3-kinase, regulatory subunit 2 (beta)
phosphoinositide-3-kinase, regulatory subunit 2 (beta)
phosphoinositide-3-kinase, regulatory subunit 2 (beta)
phosphoinositide-3-kinase, regulatory subunit 2 (beta)
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| Protein Structure | |||||||||||||||||||||||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||||||||||||||||||
| Summary |
Phosphatidylinositol 3-kinase (PI3K) is a lipid kinase that phosphorylates phosphatidylinositol and similar compounds, creating second messengers important in growth signaling pathways. PI3K functions as a heterodimer of a regulatory and a catalytic subunit. The protein encoded by this gene is a regulatory component of PI3K. Two transcript variants, one protein coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Dec 2012] |
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| Gene Information | |||||||||||||||||||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||||||||||||||||||
| Genomic Location | Chromosome 19:18153118-18170540 | ||||||||||||||||||||||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||||||||||||||||||||||
| Band | p13.11 | ||||||||||||||||||||||||||||||||||||||
| Transcripts | |||||||||||||||||||||||||||||||||||||||
| Interactions | |||||||||||||||||||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 122 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||||||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||||||||||||||||||||||
| NETPATH |
Alpha6Beta4Integrin pathway
AndrogenReceptor pathway
Notch pathway
EGFR1 pathway
KitReceptor pathway
TGF_beta_Receptor pathway
TNFalpha pathway
TCR pathway
BCR pathway
IL1 pathway
IL2 pathway
IL3 pathway
IL4 pathway
IL5 pathway
IL6 pathway
RANKL pathway
Leptin pathway
TSH pathway
Prolactin pathway
IL11 pathway
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| REACTOME |
PIP3 activates AKT signaling pathway
DAP12 signaling pathway
DAP12 interactions pathway
Role of phospholipids in phagocytosis pathway
Downstream TCR signaling pathway
Regulation of signaling by CBL pathway
Interleukin receptor SHC signaling pathway
Interleukin-3, 5 and GM-CSF signaling pathway
Interleukin-2 signaling pathway
Interleukin-7 signaling pathway
CD28 dependent PI3K/Akt signaling pathway
CD28 co-stimulation pathway
Costimulation by the CD28 family pathway
Tie2 Signaling pathway
Cell surface interactions at the vascular wall pathway
GPVI-mediated activation cascade pathway
PI3K/AKT activation pathway
GAB1 signalosome pathway
Signaling by EGFR pathway
G alpha (q) signalling events pathway
Gastrin-CREB signalling pathway via PKC and MAPK pathway
G beta:gamma signalling through PI3Kgamma pathway
G alpha (12/13) signalling events pathway
PI3K events in ERBB4 signaling pathway
Signaling by ERBB4 pathway
Rho GTPase cycle pathway
PI3K Cascade pathway
Signaling by Insulin receptor pathway
IRS-related events triggered by IGF1R pathway
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) pathway
PI3K events in ERBB2 signaling pathway
Signaling by ERBB2 pathway
PI-3K cascade pathway
Signaling by FGFR pathway
Signaling by SCF-KIT pathway
Downstream signal transduction pathway
Signaling by PDGF pathway
Synthesis of PIPs at the plasma membrane pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
Nephrin interactions pathway
Signaling by FGFR in disease pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
Downstream signaling of activated FGFR pathway
Metabolism of lipids and lipoproteins pathway
Cell-Cell communication pathway
TCR signaling pathway
Signaling by Rho GTPases pathway
Signaling by VEGF pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Cytokine Signaling in Immune system pathway
Signaling by GPCR pathway
Innate Immune System pathway
Platelet activation, signaling and aggregation pathway
G-protein beta:gamma signalling pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
GPCR downstream signaling pathway
IRS-mediated signalling pathway
Adaptive Immune System pathway
Immune System pathway
Insulin receptor signalling cascade pathway
Signaling by Interleukins pathway
VEGFA-VEGFR2 Pathway pathway
NGF signalling via TRKA from the plasma membrane pathway
PI Metabolism pathway
Phospholipid metabolism pathway
IRS-related events pathway
Fcgamma receptor (FCGR) dependent phagocytosis pathway
IGF1R signaling cascade pathway
PI3K/AKT Signaling in Cancer pathway
Metabolism pathway
Signaling by the B Cell Receptor (BCR) pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Disease pathway
Hemostasis pathway
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| KEGG |
Regulation of actin cytoskeleton pathway
mTOR signaling pathway pathway
Acute myeloid leukemia pathway
VEGF signaling pathway pathway
Fc epsilon RI signaling pathway pathway
Colorectal cancer pathway
Non-small cell lung cancer pathway
ErbB signaling pathway pathway
Renal cell carcinoma pathway
Apoptosis pathway
Melanoma pathway
Endometrial cancer pathway
Leukocyte transendothelial migration pathway
Glioma pathway
Small cell lung cancer pathway
Phosphatidylinositol signaling system pathway
Insulin signaling pathway pathway
B cell receptor signaling pathway pathway
Prostate cancer pathway
Focal adhesion pathway
T cell receptor signaling pathway pathway
Toll-like receptor signaling pathway pathway
Jak-STAT signaling pathway pathway
Type II diabetes mellitus pathway
Natural killer cell mediated cytotoxicity pathway
Chronic myeloid leukemia pathway
Pancreatic cancer pathway
Fc gamma R-mediated phagocytosis pathway
Neurotrophin signaling pathway pathway
Chemokine signaling pathway pathway
Pathways in cancer pathway
Progesterone-mediated oocyte maturation pathway
Aldosterone-regulated sodium reabsorption pathway
Amoebiasis pathway
Bacterial invasion of epithelial cells pathway
Chagas disease (American trypanosomiasis) pathway
Osteoclast differentiation pathway
Toxoplasmosis pathway
Carbohydrate digestion and absorption pathway
Hepatitis C pathway
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| INOH |
CD4 T cell receptor signaling pathway
IL-7 signaling pathway
B cell receptor signaling pathway
EPO signaling pathway pathway
Insulin receptor signaling pathway
IGF1 signaling pathway pathway
PDGF signaling pathway pathway
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| PID NCI | |||||||||||||||||||||||||||||||||||||||
| Cross-References | |||||||||||||||||||||||||||||||||||||||
| SwissProt | |||||||||||||||||||||||||||||||||||||||
| TrEMBL | |||||||||||||||||||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||||||||||||||||||
| Entrez Gene | 5296 | ||||||||||||||||||||||||||||||||||||||
| UniGene | |||||||||||||||||||||||||||||||||||||||
| RefSeq | NM_005027 | ||||||||||||||||||||||||||||||||||||||
| HUGO | HGNC:8980 | ||||||||||||||||||||||||||||||||||||||
| OMIM | 603157 | ||||||||||||||||||||||||||||||||||||||
| CCDS | CCDS12371 | ||||||||||||||||||||||||||||||||||||||
| HPRD | |||||||||||||||||||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||||||||||||||||||
| EMBL | |||||||||||||||||||||||||||||||||||||||
| GenPept | |||||||||||||||||||||||||||||||||||||||
| RNA Seq Atlas | 5296 | ||||||||||||||||||||||||||||||||||||||