Version 5.4
Homo sapiens Gene: PCDH18
Summary
InnateDB Gene IDBG-38084.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PCDH18
Gene Name protocadherin 18
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000189184
Encoded Proteins
IDBP-38086
protocadherin 18
IDBP-377734
protocadherin 18
IDBP-479280
protocadherin 18
IDBP-477659
protocadherin 18
IDBP-475437
protocadherin 18
IDBP-808391
protocadherin 18
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. This gene encodes a protein which contains 6 extracellular cadherin domains, a transmembrane domain and a cytoplasmic tail differing from those of the classical cadherins. Although its specific function is undetermined, the cadherin-related neuronal receptor is thought to play a role in the establishment and function of specific cell-cell connections in the brain. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:137518918-137532494
Strand Reverse strand
Band q28.3
Transcripts
ENST00000344876 ENSP00000355082
ENST00000412923 ENSP00000390688
ENST00000507846 ENSP00000425903
ENST00000510305 ENSP00000424269
ENST00000511115 ENSP00000425647
ENST00000611581 ENSP00000478176
ENST00000620262
ENST00000617302
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
Biological Process
GO:0007156 homophilic cell adhesion
GO:0007420 brain development
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000037892
View Gene Order
ENSBTAG00000015549
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.518989 Hs.591691 Hs.738416
RefSeq NM_001300828 NM_019035 XM_005263070 XM_006714239
HUGO
OMIM
CCDS CCDS34064 CCDS75193
HPRD 12205
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca