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InnateDB Gene
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IDBG-38225.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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WT1-AS
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Gene Name
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WT1 antisense RNA
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Synonyms
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Species
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Homo sapiens
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Ensembl Gene
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ENSG00000183242
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Encoded Proteins
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Protein Structure
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Useful resources
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Stemformatics
EHFPI
ImmGen
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| Summary |
This gene is located upstream of the Wilms tumor 1 (WT1) gene; these two genes are bi-directionally transcribed from the same promoter region. The WT1 gene is a tumor suppressor gene that has been implicated in Wilms tumor, and it is expressed in cells of mesodermal origin. This gene and the WT1 gene have the same temporal and cell-restricted expression pattern, although the expression of this gene is less abundant than WT1 expression. WT1 is involved in the development of the urogenital system, whereas the role of this gene in embryogenesis is unclear. This gene appears to produce antisense RNA transcripts that help regulate the WT1 gene. This gene is imprinted in kidney, with preferential expression from the paternal allele, and it has been proposed that imprinting defects at chromosome 11p13 may contribute to Wilms' tumourigenesis. [provided by RefSeq, Oct 2010]
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| Type |
antisense
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Genomic Location
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Chromosome 11:32435518-32458769
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Strand
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Forward strand
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Band
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p13
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Transcripts
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
| Experimentally validated |
| Total |
2
[view]
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| Protein-Protein |
0
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| Protein-DNA |
2
[view]
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| Protein-RNA |
0
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| DNA-DNA |
0
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| RNA-RNA |
0
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| DNA-RNA |
0
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No orthologs found for this gene |
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SwissProt
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TrEMBL
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UniProt Splice Variant
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Entrez Gene
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51352
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UniGene
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Hs.738474
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RefSeq
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HUGO
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HGNC:18135
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OMIM
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607899
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CCDS
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| HPRD |
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IMGT
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EMBL
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GenPept
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RNA Seq Atlas
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51352
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Version 5.4