Version 5.4
Homo sapiens Gene: SSH2
Summary
InnateDB Gene IDBG-38695.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SSH2
Gene Name slingshot homolog 2 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000141298
Encoded Proteins
IDBP-38697
slingshot homolog 2 (Drosophila)
IDBP-584523
slingshot homolog 2 (Drosophila)
IDBP-763890
IDBP-760343
IDBP-758824
IDBP-759334
IDBP-757860
IDBP-760271
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002 [PubMed 11832213]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:29625938-29930276
Strand Reverse strand
Band q11.2
Transcripts
ENST00000269033 ENSP00000269033
ENST00000324677
ENST00000394848
ENST00000540801 ENSP00000444743
ENST00000578411
ENST00000577483
ENST00000579040 ENSP00000462605
ENST00000577991 ENSP00000465703
ENST00000592397 ENSP00000467164
ENST00000582084 ENSP00000462583
ENST00000579954 ENSP00000468037
ENST00000590153 ENSP00000466607
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003779 actin binding
GO:0004721 phosphoprotein phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0008138 protein tyrosine/serine/threonine phosphatase activity
GO:0016791 phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0008064 regulation of actin polymerization or depolymerization
GO:0010591 regulation of lamellipodium assembly
GO:0016311 dephosphorylation
GO:0030036 actin cytoskeleton organization
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0050770 regulation of axonogenesis
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000037926
View Gene Order
ENSBTAG00000011011
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.654754
RefSeq NM_001282129 NM_001282130 NM_033389 XM_005258058 XM_005258059 XM_005258060 XM_006722149 XM_006722150
HUGO
OMIM
CCDS CCDS11253 CCDS74024
HPRD 09487
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca