Version 5.4
Homo sapiens Gene: TSTA3
Summary
InnateDB Gene IDBG-38856.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TSTA3
Gene Name tissue specific transplantation antigen P35B
Synonyms FX; P35B; SDR4E1
Species Homo sapiens
Ensembl Gene ENSG00000104522
Encoded Proteins
IDBP-377535
tissue specific transplantation antigen P35B
IDBP-590228
tissue specific transplantation antigen P35B
IDBP-588583
tissue specific transplantation antigen P35B
IDBP-603553
tissue specific transplantation antigen P35B
IDBP-588335
tissue specific transplantation antigen P35B
IDBP-596819
tissue specific transplantation antigen P35B
IDBP-600178
tissue specific transplantation antigen P35B
IDBP-585086
tissue specific transplantation antigen P35B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Tissue specific transplantation antigen P35B is a NADP(H)-binding protein. It catalyze the two-step epimerase and the reductase reactions in GDP-D-mannose metabolism, converting GDP-4-keto-6-D-deoxymannose to GDP-L-fucose. GDP-L-fucose is the substrate of several fucosyltransferases involved in the expression of many glycoconjugates, including blood group ABH antigens and developmental adhesion antigens. Mutations in this gene may cause leukocyte adhesion deficiency, type II. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:143612618-143618048
Strand Reverse strand
Band q24.3
Transcripts
ENST00000425753 ENSP00000398803
ENST00000524719 ENSP00000432088
ENST00000528920
ENST00000529064 ENSP00000435386
ENST00000531473
ENST00000527677
ENST00000529048 ENSP00000431587
ENST00000532308
ENST00000533817 ENSP00000437012
ENST00000530474 ENSP00000436405
ENST00000525274
ENST00000527549
ENST00000526290 ENSP00000433331
ENST00000527006 ENSP00000435240
ENST00000529899
ENST00000531006
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0009055 electron carrier activity
GO:0016853 isomerase activity
GO:0042356 GDP-4-dehydro-D-rhamnose reductase activity
GO:0050577 GDP-L-fucose synthase activity
GO:0050662 coenzyme binding
Biological Process
GO:0007159 leukocyte cell-cell adhesion
GO:0019673 GDP-mannose metabolic process
GO:0019835 cytolysis
GO:0042351 'de novo' GDP-L-fucose biosynthetic process
GO:0044237 cellular metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022570
View Gene Order
ENSBTAG00000034691
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00520
Amino sugar and nucleotide sugar metabolism pathway
hsa00051
Fructose and mannose metabolism pathway
INOH
INOH website
Fructose Mannose metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.404119
RefSeq NM_003313 XM_005251050 XM_005251051 XM_005251052 XM_006725093 XM_006725094
HUGO
OMIM
CCDS CCDS6408
HPRD 00654
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca