InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TNNC1

Summary

InnateDB Gene

IDBG-38997.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TNNC1

Gene Name

troponin C type 1 (slow)

Synonyms

CMD1Z; CMH13; TN-C; TNC; TNNC

Species

Homo sapiens

Ensembl Gene

ENSG00000114854

Encoded Proteins

IDBP-38999

troponin C type 1 (slow)

IDBP-476665

troponin C type 1 (slow)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Troponin is a central regulatory protein of striated muscle contraction, and together with tropomyosin, is located on the actin filament. Troponin consists of 3 subunits: TnI, which is the inhibitor of actomyosin ATPase; TnT, which contains the binding site for tropomyosin; and TnC, the protein encoded by this gene. The binding of calcium to TnC abolishes the inhibitory action of TnI, thus allowing the interaction of actin with myosin, the hydrolysis of ATP, and the generation of tension. Mutations in this gene are associated with cardiomyopathy dilated type 1Z. [provided by RefSeq, Oct 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:52451102-52454070

Strand

Reverse strand

Band

p21.1

Transcripts

ENST00000232975	ENSP00000232975
ENST00000496590	ENSP00000420596
ENST00000461086

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0031013	troponin I binding
GO:0031014	troponin T binding
GO:0042803	protein homodimerization activity
GO:0048306	calcium-dependent protein binding
GO:0051015	actin filament binding

Biological Process

GO:0002086	diaphragm contraction
GO:0006937	regulation of muscle contraction
GO:0010038	response to metal ion
GO:0030049	muscle filament sliding
GO:0032972	regulation of muscle filament sliding speed
GO:0043462	regulation of ATPase activity
GO:0055010	ventricular cardiac muscle tissue morphogenesis
GO:0060048	cardiac muscle contraction

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0005861	troponin complex
GO:0015629	actin cytoskeleton
GO:0043292	contractile fiber

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000091898

View Gene Order

ENSBTAG00000045757

Not yet available

Pathways

NETPATH

REACTOME

REACT_16969

Striated Muscle Contraction pathway

REACT_17044

Muscle contraction pathway

KEGG

hsa04020

Calcium signaling pathway pathway

hsa05410

Hypertrophic cardiomyopathy (HCM) pathway

hsa04260

Cardiac muscle contraction pathway

hsa05414

Dilated cardiomyopathy pathway

INOH

PID NCI

Cross-References

SwissProt

P63316

TrEMBL

C9JDI3 Q6FH91

UniProt Splice Variant

Entrez Gene

7134

UniGene

RefSeq

NM_003280

HUGO

HGNC:11943

OMIM

191040

CCDS

CCDS2857

HPRD

IMGT

EMBL

AC006208 AF020769 AK313743 BC030244 CH471055 CR541865 CR541885 GU324920 M37984 X07897

GenPept

AAA36772 AAB91994 AAH30244 ADL14491 BAG36483 CAA30736 CAG46663 CAG46683 EAW65226 EAW65227

RNA Seq Atlas

7134