Homo sapiens Gene: NFATC4 | |||||||||||||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||||||||||||
InnateDB Gene | IDBG-3927.6 | ||||||||||||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||||||||
Gene Symbol | NFATC4 | ||||||||||||||||||||||||||||||||||||
Gene Name | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 | ||||||||||||||||||||||||||||||||||||
Synonyms | NF-AT3; NF-ATC4; NFAT3 | ||||||||||||||||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||||||||||||||||
Ensembl Gene | ENSG00000100968 | ||||||||||||||||||||||||||||||||||||
Encoded Proteins |
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4
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Protein Structure | |||||||||||||||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||||||||||
InnateDB Annotation | |||||||||||||||||||||||||||||||||||||
Summary |
NFATC4 is a transcription factor required for the regulation of the Toll-like receptor-activated innate inflammatory response in monocytes/macrophages. (Demonstrated in murine model)
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InnateDB Annotation from Orthologs | |||||||||||||||||||||||||||||||||||||
Summary |
[Mus musculus] Nfatc4 is a transcription factor required for the regulation of the Toll-like receptor-activated innate inflammatory response in monocytes/macrophages.
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Entrez Gene | |||||||||||||||||||||||||||||||||||||
Summary |
The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family of nuclear factors of activated T cells also participate in the formation of this complex. The product of this gene plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of the IL-2 and IL-4. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Oct 2008] This gene encodes a member of the nuclear factor of activated T cells (NFAT) protein family. The encoded protein is part of a DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor stimulation and an inducible nuclear component. NFAT proteins are activated by the calmodulin-dependent phosphatase, calcineurin. The encoded protein plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of interleukin-2 and interleukin-4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014] |
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Gene Information | |||||||||||||||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||||||||||||||
Genomic Location | Chromosome 14:24365673-24379604 | ||||||||||||||||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||||||||||||||||
Band | q12 | ||||||||||||||||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||||||||||||||||
REACTOME | |||||||||||||||||||||||||||||||||||||
KEGG |
Wnt signaling pathway pathway
Axon guidance pathway
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INOH | |||||||||||||||||||||||||||||||||||||
PID NCI |
ErbB2/ErbB3 signaling events
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Cross-References | |||||||||||||||||||||||||||||||||||||
SwissProt | Q14934 | ||||||||||||||||||||||||||||||||||||
TrEMBL | G3V4K1 | ||||||||||||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||||||||||||
Entrez Gene | 4776 | ||||||||||||||||||||||||||||||||||||
UniGene | Hs.77810 | ||||||||||||||||||||||||||||||||||||
RefSeq | NM_001136022 NM_001198965 NM_001198966 NM_001198967 NM_001288802 NM_004554 XM_006720153 | ||||||||||||||||||||||||||||||||||||
HUGO | HGNC:7778 | ||||||||||||||||||||||||||||||||||||
OMIM | 602699 | ||||||||||||||||||||||||||||||||||||
CCDS | CCDS45089 CCDS55909 CCDS55910 CCDS55911 CCDS73625 CCDS9629 | ||||||||||||||||||||||||||||||||||||
HPRD | 09096 | ||||||||||||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||||||||||||
EMBL | AK293185 AK302271 AL096870 BC008857 BC053855 EU887632 EU887633 EU887634 EU887635 EU887636 EU887637 EU887638 EU887639 EU887640 EU887641 EU887642 EU887643 EU887644 EU887645 EU887646 EU887647 EU887648 EU887649 EU887650 EU887651 EU887652 EU887653 EU887654 EU887655 L41066 | ||||||||||||||||||||||||||||||||||||
GenPept | AAA79175 AAH08857 AAH53855 ACG55652 ACG55653 ACG55654 ACG55655 ACG55656 ACG55657 ACG55658 ACG55659 ACG55660 ACG55661 ACG55662 ACG55663 ACG55664 ACG55665 ACG55666 ACG55667 ACG55668 ACG55669 ACG55670 ACG55671 ACG55672 ACG55673 ACG55674 ACG55675 BAG56726 BAG63617 | ||||||||||||||||||||||||||||||||||||
RNA Seq Atlas | 4776 | ||||||||||||||||||||||||||||||||||||