Version 5.4
Homo sapiens Gene: LRRC4
Summary
InnateDB Gene IDBG-39584.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LRRC4
Gene Name leucine rich repeat containing 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000128594
Encoded Proteins
IDBP-39586
leucine rich repeat containing 4
IDBP-482375
leucine rich repeat containing 4
IDBP-481292
leucine rich repeat containing 4
IDBP-485295
leucine rich repeat containing 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is significantly downregulated in primary brain tumors. The exact function of the protein encoded by this gene is unknown. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:128027071-128032107
Strand Reverse strand
Band q32.1
Transcripts
ENST00000249363 ENSP00000249363
ENST00000494115 ENSP00000418254
ENST00000476782 ENSP00000418093
ENST00000478726 ENSP00000417795
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0050807 regulation of synapse organization
GO:0050808 synapse organization
GO:0097119 postsynaptic density protein 95 clustering
Cellular Component
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0043197 dendritic spine
GO:0044309 neuron spine
GO:0045202 synapse
GO:0045211 postsynaptic membrane
GO:0060076 excitatory synapse
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000049939
View Gene Order
ENSBTAG00000010704
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04514
Cell adhesion molecules (CAMs) pathway
hsa04360
Axon guidance pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL C9J7V8
UniProt Splice Variant
Entrez Gene 64101
UniGene Hs.655003
RefSeq NM_022143
HUGO HGNC:15586
OMIM 610486
CCDS CCDS5799
HPRD 10060
IMGT
EMBL AC008039
GenPept
RNA Seq Atlas 64101

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca