InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: LEP

Summary

InnateDB Gene

IDBG-39587.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LEP

Gene Name

leptin

Synonyms

LEPD; OB; OBS

Species

Homo sapiens

Ensembl Gene

ENSG00000174697

Encoded Proteins

IDBP-39589

leptin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 23341537

LEP upregulates TLR2 expression in monocytes, and may potentiate innate immunity and inflammation in hyperleptinemia conditions, such as obesity and type 2 diabetes mellitus.

PMID 23341537

LEP (leptin) upregulates TLR2 in human monocytes.

Entrez Gene

Summary

This gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:128241284-128257628

Strand

Forward strand

Band

q32.1

Transcripts

ENST00000308868

ENSP00000312652

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	9 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005179	hormone activity
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0051428	peptide hormone receptor binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001542	ovulation from ovarian follicle
GO:0001666	response to hypoxia
GO:0001819	positive regulation of cytokine production
GO:0001890	placenta development
GO:0001932	regulation of protein phosphorylation
GO:0002021	response to dietary excess
GO:0006006	glucose metabolic process
GO:0006111	regulation of gluconeogenesis
GO:0006112	energy reserve metabolic process
GO:0006114	glycerol biosynthetic process
GO:0006629	lipid metabolic process
GO:0006635	fatty acid beta-oxidation
GO:0007165	signal transduction
GO:0007260	tyrosine phosphorylation of STAT protein
GO:0007565	female pregnancy
GO:0007584	response to nutrient
GO:0007623	circadian rhythm
GO:0008203	cholesterol metabolic process
GO:0008206	bile acid metabolic process
GO:0008217	regulation of blood pressure
GO:0008284	positive regulation of cell proliferation
GO:0008343	adult feeding behavior
GO:0009062	fatty acid catabolic process
GO:0009892	negative regulation of metabolic process
GO:0019222	regulation of metabolic process
GO:0021954	central nervous system neuron development
GO:0030073	insulin secretion
GO:0030300	regulation of intestinal cholesterol absorption
GO:0032099	negative regulation of appetite
GO:0032868	response to insulin
GO:0033197	response to vitamin E
GO:0033210	leptin-mediated signaling pathway
GO:0033686	positive regulation of luteinizing hormone secretion
GO:0035630	bone mineralization involved in bone maturation
GO:0042307	positive regulation of protein import into nucleus
GO:0042445	hormone metabolic process
GO:0042517	positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0042593	glucose homeostasis
GO:0042755	eating behavior
GO:0043066	negative regulation of apoptotic process
GO:0043270	positive regulation of ion transport
GO:0043410	positive regulation of MAPK cascade
GO:0045087	innate immune response (InnateDB)
GO:0045598	regulation of fat cell differentiation
GO:0045639	positive regulation of myeloid cell differentiation
GO:0045906	negative regulation of vasoconstriction
GO:0046427	positive regulation of JAK-STAT cascade
GO:0046628	positive regulation of insulin receptor signaling pathway
GO:0046881	positive regulation of follicle-stimulating hormone secretion
GO:0048639	positive regulation of developmental growth
GO:0050796	regulation of insulin secretion
GO:0050810	regulation of steroid biosynthetic process
GO:0050901	leukocyte tethering or rolling
GO:0060587	regulation of lipoprotein lipid oxidation
GO:0060612	adipose tissue development
GO:0061037	negative regulation of cartilage development
GO:0070093	negative regulation of glucagon secretion
GO:0071298	cellular response to L-ascorbic acid
GO:0071300	cellular response to retinoic acid
GO:2000366	positive regulation of STAT protein import into nucleus
GO:2000486	negative regulation of glutamine transport
GO:2000491	positive regulation of hepatic stellate cell activation