Homo sapiens Gene: PISD | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Gene | IDBG-402136.3 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | PISD | ||||||||||||||||||
Gene Name | phosphatidylserine decarboxylase | ||||||||||||||||||
Synonyms | DJ858B16; dJ858B16.2; PSD; PSDC; PSSC | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Gene | ENSG00000241878 | ||||||||||||||||||
Encoded Proteins |
phosphatidylserine decarboxylase
phosphatidylserine decarboxylase
phosphatidylserine decarboxylase
phosphatidylserine decarboxylase
phosphatidylserine decarboxylase
phosphatidylserine decarboxylase
phosphatidylserine decarboxylase
phosphatidylserine decarboxylase
phosphatidylserine decarboxylase
phosphatidylserine decarboxylase
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Protein Structure | |||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
Entrez Gene | |||||||||||||||||||
Summary |
Phosphatidylserine decarboxylases (PSDs; EC 4.1.1.65) catalyze the formation of phosphatidylethanolamine (PE) by decarboxylation of phosphatidylserine (PS). Type I PSDs, such as PISD, are targeted to the inner mitochondrial membrane by an N-terminal targeting sequence. PISD also contains a conserved LGST motif that functions as an autocatalytic cleavage site where the proenzyme is split into mature alpha and beta subunits (Schuiki and Daum, 2009 [PubMed 19165886]).[supplied by OMIM, Jul 2010] |
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Gene Information | |||||||||||||||||||
Type | Protein coding | ||||||||||||||||||
Genomic Location | Chromosome 22:31618491-31662432 | ||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||
Band | q12.2 | ||||||||||||||||||
Transcripts | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||
No orthologs found for this gene | |||||||||||||||||||
Pathways | |||||||||||||||||||
NETPATH | |||||||||||||||||||
REACTOME |
Synthesis of PE pathway
Metabolism of lipids and lipoproteins pathway
Glycerophospholipid biosynthesis pathway
Phospholipid metabolism pathway
Metabolism pathway
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KEGG |
Glycerophospholipid metabolism pathway
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INOH |
Glycine Serine metabolism pathway
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PID NCI |
FOXA1 transcription factor network
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Cross-References | |||||||||||||||||||
SwissProt | |||||||||||||||||||
TrEMBL | |||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | |||||||||||||||||||
UniGene | Hs.420559 Hs.682306 | ||||||||||||||||||
RefSeq | NM_014338 XM_005261455 XM_005261456 XM_005261457 XM_005261458 XM_005261459 XM_005261460 XM_005261461 XM_006724200 XM_006724201 XM_006724202 | ||||||||||||||||||
HUGO | |||||||||||||||||||
OMIM | |||||||||||||||||||
CCDS | CCDS13899 | ||||||||||||||||||
HPRD | 17854 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | |||||||||||||||||||
GenPept | |||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||