InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: INSL3

Summary

InnateDB Gene

IDBG-405522.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

INSL3

Gene Name

insulin-like 3 (Leydig cell)

Synonyms

ley-I-L; RLF; RLNL

Species

Homo sapiens

Ensembl Gene

ENSG00000248099

Encoded Proteins

IDBP-37203

insulin-like 3 (Leydig cell)

IDBP-37205

insulin-like 3 (Leydig cell)

IDBP-761332

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the insulin-like hormone superfamily. The encoded protein is mainly produced in gonadal tissues. Studies of the mouse counterpart suggest that this gene may be involved in the development of urogenital tract and female fertility. This protein may also act as a hormone to regulate growth and differentiation of gubernaculum, and thus mediating intra-abdominal testicular descent. Mutations in this gene may lead to cryptorchidism. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:17816512-17821574

Strand

Reverse strand

Band

p13.11

Transcripts

ENST00000379695	ENSP00000369017
ENST00000317306	ENSP00000321724
ENST00000598577	ENSP00000469309

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001664	G-protein coupled receptor binding
GO:0002020	protease binding
GO:0005102	receptor binding
GO:0005158	insulin receptor binding
GO:0005179	hormone activity

Biological Process

GO:0001556	oocyte maturation
GO:0001701	in utero embryonic development
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007267	cell-cell signaling
GO:0007283	spermatogenesis
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0008584	male gonad development
GO:0030819	positive regulation of cAMP biosynthetic process
GO:0043066	negative regulation of apoptotic process