Version 5.4
Homo sapiens Gene: SELK
Summary
InnateDB Gene IDBG-40608.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SELK
Gene Name selenoprotein K
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000113811
Encoded Proteins
IDBP-474934
Selenoprotein K
IDBP-482068
Selenoprotein K
IDBP-604013
Selenoprotein K
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21849499
SELK is a novel target for calpain protease and its cleavage is regulated by the calpain/calpastatin system during Toll-like receptor (TLR)-induced activation of macrophages. (Demonstrated in murine model)
InnateDB Annotation from Orthologs
Summary
PMID 21849499
[Mus musculus] Selk is a novel target for calpain protease and its cleavage is regulated by the calpain/calpastatin system during Toll-like receptor (TLR)-induced activation of macrophages.
Entrez Gene
Summary This gene encodes a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This selenoprotein is localized to the endoplasmic reticulum and is highly expressed in the heart, where it may function as an antioxidant. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:53884410-53891988
Strand Reverse strand
Band p21.1
Transcripts
ENST00000495461 ENSP00000418813
ENST00000488746 ENSP00000417272
ENST00000487571
ENST00000485414
ENST00000541726 ENSP00000443164
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006816 calcium ion transport
GO:0010742 macrophage derived foam cell differentiation
GO:0018345 protein palmitoylation
GO:0030335 positive regulation of cell migration
GO:0042102 positive regulation of T cell proliferation
GO:0045087 innate immune response (InnateDB)
GO:0045728 respiratory burst after phagocytosis
GO:0051223 regulation of protein transport
GO:2000406 positive regulation of T cell migration
Cellular Component
GO:0005789 endoplasmic reticulum membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000042682
View Gene Order
ENSBTAG00000032374
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.603929
RefSeq NM_021237
HUGO
OMIM
CCDS CCDS54597
HPRD 07448
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca