InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TICAM2

Summary

InnateDB Gene

IDBG-406966.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TICAM2

Gene Name

toll-like receptor adaptor molecule 2

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000243414

Encoded Proteins

IDBP-374890

toll-like receptor adaptor molecule 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21494017

TICAM2 deficiency results in the impairment of LPS-stimulated TNF-alpha protein translation. (Demonstrated in murine model)

PMID 24297182

ARF6 regulates LPS internalization and LPS-induced relocation of TICAM2 (TRAM), which is required for the MyD88-independent TLR4 signalling cascade.

PMID 24255114

The homotypic interaction of TICAM2 Toll/interleukin-1 receptor (TIR) domain is essential to form a scaffold for recruiting the TICAM1 TIR domain.

Entrez Gene

Summary

This locus represents naturally occurring read-through transcription between the neighboring transmembrane emp24 protein transport domain containing 7 (TMED7) and toll-like receptor adaptor molecule 2 (TICAM2) genes. Alternative splicing results in multiple transcript variants, one of which encodes a fusion protein that shares sequence identity with the products of each individual gene. This fusion product functions to negatively regulate the adaptor MyD88-independent toll-like receptor 4 pathway. [provided by RefSeq, Nov 2010] TIRP is a Toll/interleukin-1 receptor (IL1R; MIM 147810) (TIR) domain-containing adaptor protein involved in Toll receptor signaling (see TLR4; MIM 603030).[supplied by OMIM, Apr 2004]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:115578650-115602479

Strand

Reverse strand

Band

q22.3

Transcripts

ENST00000427199	ENSP00000415139
ENST00000513729

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.

Experimentally validated
Total	23 [view]
Protein-Protein	23 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0005543	phospholipid binding

Biological Process

GO:0001817	regulation of cytokine production
GO:0002224	toll-like receptor signaling pathway
GO:0002756	MyD88-independent toll-like receptor signaling pathway
GO:0006954	inflammatory response
GO:0007165	signal transduction
GO:0007249	I-kappaB kinase/NF-kappaB signaling
GO:0032729	positive regulation of interferon-gamma production
GO:0032755	positive regulation of interleukin-6 production
GO:0034138	toll-like receptor 3 signaling pathway
GO:0034142	toll-like receptor 4 signaling pathway
GO:0034144	negative regulation of toll-like receptor 4 signaling pathway
GO:0034145	positive regulation of toll-like receptor 4 signaling pathway
GO:0035666	TRIF-dependent toll-like receptor signaling pathway
GO:0035669	TRAM-dependent toll-like receptor 4 signaling pathway
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087	innate immune response (InnateDB)
GO:0070671	response to interleukin-12
GO:0071222	cellular response to lipopolysaccharide
GO:0071650	negative regulation of chemokine (C-C motif) ligand 5 production
GO:0071651	positive regulation of chemokine (C-C motif) ligand 5 production
GO:2000494	positive regulation of interleukin-18-mediated signaling pathway

Cellular Component

GO:0005768	endosome
GO:0005769	early endosome
GO:0005770	late endosome
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0010008	endosome membrane
GO:0031901	early endosome membrane
GO:0031902	late endosome membrane