Homo sapiens Gene: INMT
Summary
InnateDB Gene IDBG-407426.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol INMT
Gene Name indolethylamine N-methyltransferase
Synonyms TEMT
Species Homo sapiens
Ensembl Gene ENSG00000241644
Encoded Proteins
indolethylamine N-methyltransferase
indolethylamine N-methyltransferase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary N-methylation of endogenous and xenobiotic compounds is a major method by which they are degraded. This gene encodes an enzyme that N-methylates indoles such as tryptamine. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream FAM188B (family with sequence similarity 188, member B) gene. [provided by RefSeq, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:30697985-30757602
Strand Forward strand
Band p14.3
Transcripts
ENST00000013222 ENSP00000013222
ENST00000409539 ENSP00000386961
ENST00000484180
ENST00000461246
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004790 thioether S-methyltransferase activity
GO:0008168 methyltransferase activity
GO:0030748 amine N-methyltransferase activity
Biological Process
GO:0009308 amine metabolic process
GO:0009636 response to toxic substance
GO:0032259 methylation
Cellular Component
GO:0005829 cytosol
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
Tryptophan metabolism pathway
Selenocompound metabolism pathway
INOH
Tryptophan degradation pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.619219 Hs.632629
RefSeq NM_001199219 NM_006774
HUGO
OMIM
CCDS CCDS5430 CCDS56479
HPRD 06890
IMGT
EMBL
GenPept
RNA Seq Atlas