InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: UGT1A4

Summary

InnateDB Gene

IDBG-407472.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UGT1A4

Gene Name

UDP glucuronosyltransferase 1 family, polypeptide A4

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000244474

Encoded Proteins

IDBP-83566

UDP glucuronosyltransferase 1 family, polypeptide A4

IDBP-389401

UDP glucuronosyltransferase 1 family, polypeptide A4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. This enzyme has some glucuronidase activity towards bilirubin, although is is more active on amines, steroids, and sapogenins. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:233718778-233773299

Strand

Forward strand

Band

q37.1

Transcripts

ENST00000373409	ENSP00000362508
ENST00000450233	ENSP00000408608

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0015020	glucuronosyltransferase activity
GO:0016758	transferase activity, transferring hexosyl groups
GO:0019899	enzyme binding
GO:0030246	carbohydrate binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006805	xenobiotic metabolic process
GO:0008152	metabolic process
GO:0030259	lipid glycosylation
GO:0044281	small molecule metabolic process
GO:0052695	cellular glucuronidation

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane

Orthologs

No orthologs found for this gene

Pathways

NETPATH

REACTOME

REACT_22297

Heme degradation pathway

REACT_6784

Glucuronidation pathway

REACT_9431

Metabolism of porphyrins pathway

REACT_6959

Phase II conjugation pathway

REACT_111217

Metabolism pathway

REACT_13433

Biological oxidations pathway

KEGG

hsa00830

Retinol metabolism pathway

hsa00040

Pentose and glucuronate interconversions pathway

hsa00500

Starch and sucrose metabolism pathway

hsa00140

Steroid hormone biosynthesis pathway

hsa00053

Ascorbate and aldarate metabolism pathway

hsa00980

Metabolism of xenobiotics by cytochrome P450 pathway

hsa00860

Porphyrin and chlorophyll metabolism pathway

hsa00982

Drug metabolism pathway

hsa00983

Drug metabolism pathway

INOH

PID NCI

Cross-References

SwissProt

P22310

TrEMBL

B8K2E8 Q53QD2 Q8WX88

UniProt Splice Variant

Entrez Gene

54657

UniGene

Hs.643992

RefSeq

NM_007120

HUGO

HGNC:12536

OMIM

191740 606429

CCDS

CCDS33405

HPRD

IMGT

EMBL

AC006985 AC114812 AF297093 AF465195 AK313623 AY435139 AY724463 BC139784 CH471063 DQ364249 DQ445936 DQ445938 DQ445940 DQ445941 DQ445944 DQ445947 M57951 M84122 M84123 M84124 M84128

GenPept

AAA61247 AAA61249 AAA63196 AAG30422 AAI39785 AAL73503 AAR95640 AAY24023 AAY32626 ABC96773 ABE01866 ABE01868 ABE01870 ABE01871 ABE01874 ABE01877 BAG36384 EAW71061

RNA Seq Atlas

54657