Version 5.4
Homo sapiens Gene: CALB2
Summary
InnateDB Gene IDBG-40813.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CALB2
Gene Name calbindin 2
Synonyms CAB29; CAL2; CR
Species Homo sapiens
Ensembl Gene ENSG00000172137
Encoded Proteins
IDBP-40815
calbindin 2
IDBP-40817
calbindin 2
IDBP-750255
IDBP-746698
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an intracellular calcium-binding protein belonging to the troponin C superfamily. Members of this protein family have six EF-hand domains which bind calcium. This protein plays a role in diverse cellular functions, including message targeting and intracellular calcium buffering. It also functions as a modulator of neuronal excitability, and is a diagnostic marker for some human diseases, including Hirschsprung disease and some cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:71358713-71390438
Strand Forward strand
Band q22.2
Transcripts
ENST00000302628 ENSP00000307508
ENST00000349553 ENSP00000340294
ENST00000490520 ENSP00000454467
ENST00000467817
ENST00000562305 ENSP00000454639
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
Biological Process
GO:0051480 cytosolic calcium ion homeostasis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005921 gap junction
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000003657
View Gene Order
ENSBTAG00000001075
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.106857
RefSeq NM_001740 NM_007088
HUGO
OMIM
CCDS CCDS10899
HPRD 00230
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca