Homo sapiens Gene: ADH1C
Summary
InnateDB Gene IDBG-408498.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADH1C
Gene Name alcohol dehydrogenase 1C (class I), gamma polypeptide
Synonyms ADH3;
Species Homo sapiens
Ensembl Gene ENSG00000248144
Encoded Proteins
alcohol dehydrogenase 1C (class I), gamma polypeptide
alcohol dehydrogenase 1C (class I), gamma polypeptide
alcohol dehydrogenase 1C (class I), gamma polypeptide
Protein Structure
Entrez Gene
Summary This gene encodes class I alcohol dehydrogenase, gamma subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class I alcohol dehydrogenase, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:99336492-99353027
Strand Reverse strand
Band q23
Transcripts
ENST00000511397 ENSP00000478545
ENST00000505942
ENST00000510055 ENSP00000478439
ENST00000515683 ENSP00000426083
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004022 alcohol dehydrogenase (NAD) activity
GO:0008270 zinc ion binding
GO:0016491 oxidoreductase activity
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups
Biological Process
GO:0006069 ethanol oxidation
GO:0006805 xenobiotic metabolic process
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005829 cytosol
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
Metabolism pathway
Biological oxidations pathway
Ethanol oxidation pathway
Phase 1 - Functionalization of compounds pathway
KEGG
Glycolysis / Gluconeogenesis pathway
Fatty acid degradation pathway
Tyrosine metabolism pathway
Retinol metabolism pathway
Metabolism of xenobiotics by cytochrome P450 pathway
Drug metabolism pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P00326
TrEMBL
UniProt Splice Variant
Entrez Gene 126
UniGene Hs.654537
RefSeq NM_000669
HUGO HGNC:251
OMIM 103730
CCDS
HPRD 00066
IMGT
EMBL AC097530 BC062476 BC066227 BC066228 BC067419 BC067420 BC067421 BC067422 BC074771 BC074786 D11067 DQ088981 M12272 X04299 X04350
GenPept AAC41757 AAH62476 AAH66227 AAH66228 AAH67419 AAH67420 AAH67421 AAH67422 AAH74771 AAH74786 AAY68222 BAC06856 CAA27842 CAA27876
ImmGen ADH1C (murine)
RNA Seq Atlas 126