Version 5.4
Homo sapiens Gene: CCT6B
Summary
InnateDB Gene IDBG-40853.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CCT6B
Gene Name chaperonin containing TCP1, subunit 6B (zeta 2)
Synonyms CCT-zeta-2; CCTZ-2; Cctz2; TCP-1-zeta-2; TSA303
Species Homo sapiens
Ensembl Gene ENSG00000132141
Encoded Proteins
IDBP-40855
chaperonin containing TCP1, subunit 6B (zeta 2)
IDBP-375348
chaperonin containing TCP1, subunit 6B (zeta 2)
IDBP-375350
chaperonin containing TCP1, subunit 6B (zeta 2)
IDBP-760569
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:34927859-34981078
Strand Reverse strand
Band q12
Transcripts
ENST00000314144 ENSP00000327191
ENST00000421975 ENSP00000398044
ENST00000436961 ENSP00000400917
ENST00000577307
ENST00000585073 ENSP00000462020
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
Experimentally validated
Total 20 [view]
Protein-Protein 19 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005524 ATP binding
GO:0008565 protein transporter activity
GO:0051082 unfolded protein binding
Biological Process
GO:0006457 protein folding
GO:0007283 spermatogenesis
GO:0015031 protein transport
GO:0044267 cellular protein metabolic process
GO:0051131 chaperone-mediated protein complex assembly
Cellular Component
GO:0005832 chaperonin-containing T-complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020698
View Gene Order
ENSBTAG00000020338
Not yet available
Cross-References
SwissProt Q92526
TrEMBL
UniProt Splice Variant
Entrez Gene 10693
UniGene Hs.73072
RefSeq NM_001193529 NM_001193530 NM_006584 XM_006721641
HUGO HGNC:1621
OMIM 610730
CCDS CCDS54106 CCDS32617 CCDS54105
HPRD 09873
IMGT
EMBL AC022903 AK301773 AK302344 BC026125 BC027591 D78333
GenPept AAH26125 AAH27591 BAA11347 BAG63232 BAG63672
RNA Seq Atlas 10693

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca