Homo sapiens Gene: CCT6B
Summary
InnateDB Gene IDBG-40853.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CCT6B
Gene Name chaperonin containing TCP1, subunit 6B (zeta 2)
Synonyms CCT-zeta-2; CCTZ-2; Cctz2; TCP-1-zeta-2; TSA303;
Species Homo sapiens
Ensembl Gene ENSG00000132141
Encoded Proteins
chaperonin containing TCP1, subunit 6B (zeta 2)
chaperonin containing TCP1, subunit 6B (zeta 2)
chaperonin containing TCP1, subunit 6B (zeta 2)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:34927859-34981078
Strand Reverse strand
Band q12
Transcripts
ENST00000314144 ENSP00000327191
ENST00000421975 ENSP00000398044
ENST00000436961 ENSP00000400917
ENST00000577307
ENST00000585073 ENSP00000462020
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
Experimentally validated
Total 20 [view]
Protein-Protein 19 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005524 ATP binding
GO:0008565 protein transporter activity
GO:0051082 unfolded protein binding
Biological Process
GO:0006457 protein folding
GO:0007283 spermatogenesis
GO:0015031 protein transport
GO:0044267 cellular protein metabolic process
GO:0051131 chaperone-mediated protein complex assembly
Cellular Component
GO:0005832 chaperonin-containing T-complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt
TrEMBL J3KRI6
UniProt Splice Variant
Entrez Gene 10693
UniGene Hs.73072
RefSeq NM_006584 NM_001193529 NM_001193530 XM_006721641
HUGO HGNC:1621
OMIM 610730
CCDS CCDS32617 CCDS54106 CCDS54105
HPRD 09873
IMGT
EMBL AC022903
GenPept
RNA Seq Atlas 10693