Version 5.4
Homo sapiens Gene: PCDHGB1
Summary
InnateDB Gene IDBG-408879.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PCDHGB1
Gene Name protocadherin gamma subfamily B, 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000254221
Encoded Proteins
IDBP-484496
protocadherin gamma subfamily B, 1
IDBP-808582
protocadherin gamma subfamily B, 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:141350102-141512979
Strand Forward strand
Band q31.3
Transcripts
ENST00000523390 ENSP00000429273
ENST00000611598 ENSP00000478900
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
Biological Process
GO:0007156 homophilic cell adhesion
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
No orthologs found for this gene
Cross-References
SwissProt Q9Y5G3
TrEMBL Q9BT64 Q9UKW1
UniProt Splice Variant
Entrez Gene 56104
UniGene
RefSeq NM_018922 NM_032095
HUGO HGNC:8708
OMIM 606299
CCDS CCDS54923 CCDS75330
HPRD 09389
IMGT
EMBL AF119570 AF152330 AF152517 BC004321 BC103926 BC103927 CH471062
GenPept AAD43724 AAD43777 AAF03087 AAH04321 AAI03927 AAI03928 EAW61955
RNA Seq Atlas 56104

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca