Version 5.4
| Homo sapiens Gene: ERVFRD-1 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-409030.3 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | ERVFRD-1 | ||||||||||||||||||
| Gene Name | endogenous retrovirus group FRD, member 1 | ||||||||||||||||||
| Synonyms | |||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000244476 | ||||||||||||||||||
| Encoded Proteins |
endogenous retrovirus group FRD, member 1
endogenous retrovirus group FRD, member 1
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of a human endogenous retrovirus provirus on chromosome 6 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product plays a major role in placental development and trophoblast fusion. The protein has the characteristics of a typical retroviral envelope protein, including a cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. [provided by RefSeq, Jun 2012] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 6:11102489-11111732 | ||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||
| Band | p24.2 | ||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
| No orthologs found for this gene | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | P60508 | ||||||||||||||||||
| TrEMBL | Q8NC12 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 405754 | ||||||||||||||||||
| UniGene | Hs.631996 | ||||||||||||||||||
| RefSeq | NM_207582 | ||||||||||||||||||
| HUGO | HGNC:33823 | ||||||||||||||||||
| OMIM | 610524 | ||||||||||||||||||
| CCDS | CCDS4519 | ||||||||||||||||||
| HPRD | |||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AK075092 AK123938 AL136139 AY358244 BC068585 | ||||||||||||||||||
| GenPept | AAH68585 AAQ88611 BAC11396 BAC85731 | ||||||||||||||||||
| RNA Seq Atlas | 405754 | ||||||||||||||||||