InnateDB Gene
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IDBG-409046.4
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MRPS17
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Gene Name
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28S ribosomal protein S17, mitochondrial; HCG1984214, isoform CRA_a
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Synonyms
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Species
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Homo sapiens
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Ensembl Gene
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ENSG00000249773
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Encoded Proteins
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28S ribosomal protein S17, mitochondrial
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Protein Structure
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Useful resources
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Stemformatics
EHFPI
ImmGen
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Summary |
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S17P family. The encoded protein is moderately conserved between human mitochondrial and prokaryotic ribosomal proteins. Pseudogenes corresponding to this gene are found on chromosomes 1p, 3p, 6q, 14p, 18q, and Xq. [provided by RefSeq, Jul 2008]
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Type |
Protein coding
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Genomic Location
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Chromosome 7:55887277-55955239
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Strand
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Forward strand
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Band
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p11.2
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Transcripts
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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No orthologs found for this gene |
NETPATH |
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REACTOME |
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KEGG |
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INOH |
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PID NCI |
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SwissProt
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TrEMBL
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E9PE17
I3L0E3
Q96Q59
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UniProt Splice Variant
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Entrez Gene
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51373
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UniGene
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RefSeq
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HUGO
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HGNC:14047
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OMIM
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611980
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CCDS
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HPRD |
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IMGT
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EMBL
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AB049950
AB051352
AC092579
AC092647
AF077035
BC047445
BC054031
CH471140
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GenPept
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AAD27768
AAH47445
AAH54031
BAB41003
BAB54942
EAX07962
EAX07965
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RNA Seq Atlas
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51373
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