Homo sapiens Gene: NME1

Summary
InnateDB Gene IDBG-409263.3
Last Modified 2013-04-25   [Report errors or provide feedback]
Gene Symbol NME1
Gene Name NME/NM23 nucleoside diphosphate kinase 1
Synonyms AWD; GAAD; NB; NBS; NDKA; NDPK-A; NDPKA; NM23; NM23-H1
Species Homo sapiens
Ensembl Gene ENSG00000239672
Encoded Proteins
IDBP-59614 non-metastatic cells 1, protein (NM23A) expressed in
IDBP-59616 non-metastatic cells 1, protein (NM23A) expressed in
IDBP-244095 non-metastatic cells 1, protein (NM23A) expressed in
IDBP-381897 non-metastatic cells 1, protein (NM23A) expressed in
IDBP-485172 non-metastatic cells 1, protein (NM23A) expressed in
IDBP-477315 non-metastatic cells 1, protein (NM23A) expressed in
IDBP-597592 non-metastatic cells 1, protein (NM23A) expressed in
Entrez Gene
Summary This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17: 49230897-49239789
Strand Forward strand
Band q21.33
Transcripts
ENST00000336097  ENSP00000337060
ENST00000013034  ENSP00000013034
ENST00000393196  ENSP00000376892
ENST00000456492  ENSP00000387682
ENST00000487481 
ENST00000480143  ENSP00000429318
ENST00000512768 
ENST00000511355  ENSP00000428553
ENST00000475573  ENSP00000435498
ENST00000465188 
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 72 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 72 [view]
Protein‑Protein  70
[view]
Protein‑DNA 2
[view]
Protein‑RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
 
Predicted by orthology
Total [view]
Gene Ontology
Accession GO Term
Molecular Function
GO:0000287 magnesium ion binding
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0003697 single-stranded DNA binding
GO:0004536 deoxyribonuclease activity
GO:0004550 nucleoside diphosphate kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0005525 GTP binding
GO:0019215 intermediate filament binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0042802 identical protein binding
GO:0043015 gamma-tubulin binding
Biological Process
GO:0002762 negative regulation of myeloid leukocyte differentiation
GO:0006165 nucleoside diphosphate phosphorylation
GO:0006183 GTP biosynthetic process
GO:0006228 UTP biosynthetic process
GO:0006241 CTP biosynthetic process
GO:0006897 endocytosis
GO:0007399 nervous system development
GO:0008285 negative regulation of cell proliferation
GO:0010629 negative regulation of gene expression
GO:0010976 positive regulation of neuron projection development
GO:0014075 response to amine stimulus
GO:0015949 nucleobase-containing small molecule interconversion
GO:0021766 hippocampus development
GO:0030154 cell differentiation
GO:0033574 response to testosterone stimulus
GO:0035690 cellular response to drug
GO:0042493 response to drug
GO:0042981 regulation of apoptotic process
GO:0043388 positive regulation of DNA binding
GO:0044281 small molecule metabolic process
GO:0050679 positive regulation of epithelial cell proliferation
GO:0051591 response to cAMP
GO:0055086 nucleobase-containing small molecule metabolic process
GO:0071333 cellular response to glucose stimulus
GO:0071398 cellular response to fatty acid
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005829 cytosol
GO:0016020 membrane
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Gene ID Gene Order Method Confidence Comments
ENSMUSG00000037601 RBBH Low Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
NetPath_7 TGF_beta_Receptor pathway
REACTOME
KEGG
hsa01100  Metabolic pathways
hsa00230  Purine metabolism
hsa00240  Pyrimidine metabolism
INOH
INOH website Folate metabolism
INOH website Purine nucleotides nucleosides metabolism
INOH website Pyrimidine nucleotides nucleosides metabolism
PID BIOCARTA
100099 Endocytotic role of ndk phosphins and dynamin [Biocarta view]
100035 Granzyme a mediated apoptosis pathway [Biocarta view]
PID NCI
arf6downstreampathway Arf6 downstream pathway
arf6_traffickingpathway Arf6 trafficking events
ecadherin_nascentaj_pathway E-cadherin signaling in the nascent adherens junction
ajdiss_2pathway Posttranslational regulation of adherens junction stability and dissassembly
cdc42_reg_pathway Regulation of CDC42 activity
myc_activpathway Validated targets of C-MYC transcriptional activation
Cross-References
SwissProt P15531 
TrEMBL C9K028 E5RHP0 E7ERL0
UniProt Splice Variant
Entrez Gene 4830 
UniGene
RefSeq NM_000269  NM_198175 
HUGO 7849 
OMIM 156490
CCDS CCDS11578  CCDS11579 
HPRD 01131
IMGT
EMBL AC005839 AF487339 AK291105 BC000293 BC018994 CH471109 CR542104 CR542115 X17620 X73066 X75598
GenPept AAH00293  AAH18994  AAO85436  BAF83794  CAA35621  CAA51527  CAA53270  CAG46901  CAG46912  EAW94568 
ImmGen NME1 (murine) 
RNA Seq Atlas 4830