Version 5.4
| Homo sapiens Gene: LILRA2 | |||||||||
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| Summary | |||||||||
| InnateDB Gene | IDBG-409454.3 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | LILRA2 | ||||||||
| Gene Name | leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2 | ||||||||
| Synonyms | CD85H; ILT1; LIR-7; LIR7 | ||||||||
| Species | Homo sapiens | ||||||||
| Ensembl Gene | ENSG00000239998 | ||||||||
| Encoded Proteins |
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2
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| Protein Structure | |||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||
| InnateDB Annotation | |||||||||
| Summary |
LILRA2-activation of monocytes is distinct from LPS activation, as assessed by the secreted cytokine profile. LILRA2 cross-linking also results in inhibition of FCGR1A-dependent phagocytosis in monocytes.
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| Entrez Gene | |||||||||
| Summary |
This gene encodes a member of the leukocyte Ig-like receptor (LIR) family of immunoreceptors that are expressed predominantly on monocytes and B cells, and at lower levels on dendritic cells and natural killer cells. The LIR family comprises of activating (subfamily A) and inhibitory (subfamily B) cell-surface receptors. The LIR encoded by this gene was shown to be an activating receptor for eosinophils that elicited the release of cytotoxic granule proteins, de novo lipid mediator generation, and cytokine release through vesicular transport. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011] This gene encodes a member of a family of immunoreceptors that are expressed predominantly on monocytes and B cells, and at lower levels on dendritic cells and natural killer cells. The encoded protein is an activating receptor that inhibits dendritic cell differentiation and antigen presentation and suppresses innate immune response. Alternatively spliced transcript variants encoding different isoforms have been found. This gene is located in a cluster of related genes on chromosome 19 and there is a pseudogene for this gene on chromosome 3. [provided by RefSeq, Mar 2014] |
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| Gene Information | |||||||||
| Type | Protein coding | ||||||||
| Genomic Location | Chromosome 19:54572920-54587560 | ||||||||
| Strand | Forward strand | ||||||||
| Band | q13.42 | ||||||||
| Transcripts | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||
| No orthologs found for this gene | |||||||||
| Pathways | |||||||||
| NETPATH | |||||||||
| REACTOME | |||||||||
| KEGG |
Osteoclast differentiation pathway
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| INOH | |||||||||
| PID NCI | |||||||||
| Cross-References | |||||||||
| SwissProt | |||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | |||||||||
| UniGene | |||||||||
| RefSeq | NM_001130917 NM_001290270 NM_006866 XM_006722989 | ||||||||
| HUGO | |||||||||
| OMIM | |||||||||
| CCDS | CCDS12900 CCDS46179 CCDS74453 | ||||||||
| HPRD | 11992 | ||||||||
| IMGT | |||||||||
| EMBL | |||||||||
| GenPept | |||||||||
| RNA Seq Atlas | |||||||||