Version 5.4
Homo sapiens Gene: TGM3
Summary
InnateDB Gene IDBG-41095.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TGM3
Gene Name transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase)
Synonyms TGE
Species Homo sapiens
Ensembl Gene ENSG00000125780
Encoded Proteins
IDBP-41097
transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene consists of two polypeptide chains activated from a single precursor protein by proteolysis. The encoded protein is involved the later stages of cell envelope formation in the epidermis and hair follicle. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:2296001-2341078
Strand Forward strand
Band p13
Transcripts
ENST00000381458 ENSP00000370867
ENST00000463090
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 10 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003810 protein-glutamine gamma-glutamyltransferase activity
GO:0003824 catalytic activity
GO:0005509 calcium ion binding
GO:0016746 transferase activity, transferring acyl groups
Biological Process
GO:0006464 cellular protein modification process
GO:0018149 peptide cross-linking
GO:0030216 keratinocyte differentiation
GO:0031069 hair follicle morphogenesis
GO:0031424 keratinization
GO:0043163 cell envelope organization
GO:0051262 protein tetramerization
Cellular Component
GO:0005737 cytoplasm
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027401
View Gene Order
ENSBTAG00000001785
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.2022
RefSeq NM_003245 XM_006723615
HUGO
OMIM
CCDS CCDS33435
HPRD 02584
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca