Version 5.4
Homo sapiens Gene: MEST
Summary
InnateDB Gene IDBG-41468.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MEST
Gene Name mesoderm specific transcript homolog (mouse)
Synonyms PEG1
Species Homo sapiens
Ensembl Gene ENSG00000106484
Encoded Proteins
IDBP-41470
mesoderm specific transcript homolog (mouse)
IDBP-41472
mesoderm specific transcript homolog (mouse)
IDBP-41474
mesoderm specific transcript homolog (mouse)
IDBP-386327
mesoderm specific transcript homolog (mouse)
IDBP-244123
mesoderm specific transcript homolog (mouse)
IDBP-386323
mesoderm specific transcript homolog (mouse)
IDBP-386324
mesoderm specific transcript homolog (mouse)
IDBP-386328
mesoderm specific transcript homolog (mouse)
IDBP-386329
mesoderm specific transcript homolog (mouse)
IDBP-386331
mesoderm specific transcript homolog (mouse)
IDBP-386334
mesoderm specific transcript homolog (mouse)
IDBP-386335
mesoderm specific transcript homolog (mouse)
IDBP-812282
mesoderm specific transcript
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the alpha/beta hydrolase superfamily. It is imprinted, exhibiting preferential expression from the paternal allele in fetal tissues, and isoform-specific imprinting in lymphocytes. The loss of imprinting of this gene has been linked to certain types of cancer and may be due to promotor switching. The encoded protein may play a role in development. Alternatively spliced transcript variants encoding multiple isoforms have been identified for this gene. Pseudogenes of this gene are located on the short arm of chromosomes 3 and 4, and the long arm of chromosomes 6 and 15. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:130486171-130506296
Strand Forward strand
Band q32.2
Transcripts
ENST00000341441 ENSP00000342749
ENST00000378576 ENSP00000367839
ENST00000223215 ENSP00000223215
ENST00000399874 ENSP00000390589
ENST00000393187 ENSP00000376884
ENST00000416162 ENSP00000408933
ENST00000427521 ENSP00000409505
ENST00000433159 ENSP00000409768
ENST00000421001 ENSP00000407222
ENST00000437945 ENSP00000401657
ENST00000437637 ENSP00000393709
ENST00000458161 ENSP00000396504
ENST00000460590
ENST00000462132
ENST00000475188
ENST00000494868
ENST00000463263 ENSP00000473492
ENST00000488093
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 30 experimentally validated interaction(s) in this database.
Experimentally validated
Total 30 [view]
Protein-Protein 30 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0016787 hydrolase activity
Biological Process
GO:0007498 mesoderm development
GO:0008152 metabolic process
GO:0010883 regulation of lipid storage
GO:0032526 response to retinoic acid
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000051855
View Gene Order
ENSBTAG00000017223
Not yet available
Cross-References
SwissProt Q5EB52
TrEMBL C9JCM6 C9JG66 C9JRA9 C9JSW2 C9JUD2 C9JWU9
UniProt Splice Variant
Entrez Gene 4232
UniGene Hs.596119
RefSeq NM_001253900 NM_001253901 NM_001253902 NM_002402 NM_177524 NM_177525
HUGO HGNC:7028
OMIM 601029
CCDS CCDS59081 CCDS5822 CCDS5823
HPRD 06776
IMGT
EMBL AB045582 AC007938 AK312688 BC002413 BC011908 BC014564 BC018695 BC090049 BT007056 CH471070 CR457040 CR627364 D78611 D87367 Y11534
GenPept AAH02413 AAH11908 AAH14564 AAH18695 AAH90049 AAP35705 BAA11432 BAA21757 BAC02716 BAG35568 CAA72297 CAG33321 CAH10465 EAW83766
RNA Seq Atlas 4232

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca