Version 5.4
Homo sapiens Gene: MKLN1
Summary
InnateDB Gene IDBG-41646.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MKLN1
Gene Name muskelin 1, intracellular mediator containing kelch motifs
Synonyms TWA2
Species Homo sapiens
Ensembl Gene ENSG00000128585
Encoded Proteins
IDBP-41648
muskelin 1, intracellular mediator containing kelch motifs
IDBP-386368
muskelin 1, intracellular mediator containing kelch motifs
IDBP-386370
muskelin 1, intracellular mediator containing kelch motifs
IDBP-386372
muskelin 1, intracellular mediator containing kelch motifs
IDBP-386373
muskelin 1, intracellular mediator containing kelch motifs
IDBP-386374
muskelin 1, intracellular mediator containing kelch motifs
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Muskelin is an intracellular protein that acts as a mediator of cell spreading and cytoskeletal responses to the extracellular matrix component thrombospondin I (MIM 188060) (Adams et al., 1998 [PubMed 9724633]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:131110096-131496636
Strand Forward strand
Band q32.3
Transcripts
ENST00000352689 ENSP00000323527
ENST00000421797 ENSP00000398094
ENST00000416992 ENSP00000387920
ENST00000429546 ENSP00000399954
ENST00000446815 ENSP00000412815
ENST00000458153 ENSP00000407705
ENST00000494286
ENST00000494785
ENST00000498778
ENST00000497746
ENST00000496815
ENST00000468830
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated
Total 16 [view]
Protein-Protein 14 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007155 cell adhesion
GO:0007165 signal transduction
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025609
View Gene Order
ENSBTAG00000010437
Not yet available
Cross-References
SwissProt
TrEMBL C9JVL5 C9JWX9
UniProt Splice Variant
Entrez Gene 4289
UniGene Hs.44693
RefSeq NM_001145354 NM_013255 XM_005250355 XM_005250356
HUGO HGNC:7109
OMIM 605623
CCDS CCDS34754
HPRD 16129
IMGT
EMBL AC008264 AC009362 AC009783 AC013434 AC018642
GenPept
RNA Seq Atlas 4289

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca