Version 5.4
Homo sapiens Gene: STS
Summary
InnateDB Gene IDBG-41982.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol STS
Gene Name steroid sulfatase (microsomal), isozyme S
Synonyms ARSC; ARSC1; ASC; ES; SSDD; XLI
Species Homo sapiens
Ensembl Gene ENSG00000101846
Encoded Proteins
IDBP-41984
steroid sulfatase (microsomal), isozyme S
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene catalyzes the conversion of sulfated steroid precursors to estrogens during pregnancy. The encoded protein is found in the endoplasmic reticulum, where it acts as a homodimer. Mutations in this gene are known to cause X-linked ichthyosis (XLI). [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:7219456-7354810
Strand Forward strand
Band p22.31
Transcripts
ENST00000217961 ENSP00000217961
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004773 steryl-sulfatase activity
GO:0008484 sulfuric ester hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0006665 sphingolipid metabolic process
GO:0006687 glycosphingolipid metabolic process
GO:0006706 steroid catabolic process
GO:0007565 female pregnancy
GO:0008152 metabolic process
GO:0008544 epidermis development
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005764 lysosome
GO:0005768 endosome
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043231 intracellular membrane-bounded organelle
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_121036
The activation of arylsulfatases pathway
REACT_116105
Glycosphingolipid metabolism pathway
REACT_19323
Sphingolipid metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_22161
Post-translational protein modification pathway
REACT_1069
PTM: gamma carboxylation, hypusine formation and arylsulfatase activation pathway
REACT_17015
Metabolism of proteins pathway
REACT_111217
Metabolism pathway
KEGG
hsa00140
Steroid hormone biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt P08842
TrEMBL
UniProt Splice Variant
Entrez Gene 412
UniGene Hs.522578
RefSeq NM_000351 XM_005274511 XM_006724488
HUGO HGNC:11425
OMIM 300747
CCDS CCDS14127
HPRD 02389
IMGT
EMBL AK314034 BC075030 J04964 M16505 M23556 M23945
GenPept AAA60596 AAA60597 AAA60598 AAA60599 AAH75030 BAG36744
RNA Seq Atlas 412

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca