Version 5.4
Homo sapiens Gene: WWC3
Summary
InnateDB Gene IDBG-42760.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WWC3
Gene Name WWC family member 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000047644
Encoded Proteins
IDBP-42762
WWC family member 3
IDBP-361733
WWC family member 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the WWC family of proteins, which also includes the WWC1 (KIBRA) gene product and the WWC2 gene product. The protein encoded by this gene includes a C2 domain, which is known to mediate homodimerization in the related WWC1 gene product. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome X:10015562-10144478
Strand Forward strand
Band p22.2
Transcripts
ENST00000380861 ENSP00000370242
ENST00000454666 ENSP00000399584
ENST00000466248
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019900 kinase binding
GO:0032947 protein complex scaffold
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0035331 negative regulation of hippo signaling
GO:0046621 negative regulation of organ growth
Cellular Component
GO:0005829 cytosol
Orthologs
No orthologs found for this gene
Cross-References
SwissProt Q9ULE0
TrEMBL T2C6S4
UniProt Splice Variant
Entrez Gene 55841
UniGene Hs.527524 Hs.614425
RefSeq NM_015691
HUGO HGNC:29237
OMIM
CCDS CCDS14136
HPRD 11136
IMGT
EMBL AB033106 AC002359 AC002364 AC121345 AK292961 AL353937 BC003527 CH471074 KC987947
GenPept AAH03527 AGV22437 BAA86594 BAF85650 CAH56367 EAW98775
RNA Seq Atlas 55841

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca