Version 5.4
Homo sapiens Gene: HCCS
Summary
InnateDB Gene IDBG-43460.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HCCS
Gene Name holocytochrome c synthase
Synonyms CCHL; MCOPS7; MLS
Species Homo sapiens
Ensembl Gene ENSG00000004961
Encoded Proteins
IDBP-43462
holocytochrome c synthase
IDBP-43464
holocytochrome c synthase
IDBP-43466
holocytochrome c synthase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is an enzyme that covalently links a heme group to the apoprotein of cytochrome c. Defects in this gene are a cause of microphthalmia syndromic type 7 (MCOPS7). Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jan 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome X:11111301-11123078
Strand Forward strand
Band p22.2
Transcripts
ENST00000321143 ENSP00000326579
ENST00000380763 ENSP00000370140
ENST00000380762 ENSP00000370139
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004408 holocytochrome-c synthase activity
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0009887 organ morphogenesis
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031352
View Gene Order
ENSBTAG00000012113
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00860
Porphyrin and chlorophyll metabolism pathway
INOH
PID NCI
Cross-References
SwissProt P53701
TrEMBL A0A024RBY9
UniProt Splice Variant
Entrez Gene 3052
UniGene Hs.211571
RefSeq NM_001122608 NM_001171991 NM_005333
HUGO HGNC:4837
OMIM 300056
CCDS CCDS14139
HPRD
IMGT
EMBL AF053010 AF053011 AF053012 AF053013 AF053014 AF053015 AK097815 BC001691 BC095455 CH471074 U36787
GenPept AAB19007 AAC35274 AAH01691 AAH95455 BAG53533 EAW98783 EAW98784 EAW98785
RNA Seq Atlas 3052

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca