Version 5.4
Homo sapiens Gene: TBXAS1
Summary
InnateDB Gene IDBG-43840.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TBXAS1
Gene Name thromboxane A synthase 1 (platelet)
Synonyms BDPLT14; CYP5; CYP5A1; GHOSAL; THAS; TS; TXAS; TXS
Species Homo sapiens
Ensembl Gene ENSG00000059377
Encoded Proteins
IDBP-43842
thromboxane A synthase 1 (platelet)
IDBP-43844
thromboxane A synthase 1 (platelet)
IDBP-386815
thromboxane A synthase 1 (platelet)
IDBP-386816
thromboxane A synthase 1 (platelet)
IDBP-386817
thromboxane A synthase 1 (platelet)
IDBP-386819
thromboxane A synthase 1 (platelet)
IDBP-386820
thromboxane A synthase 1 (platelet)
IDBP-386826
thromboxane A synthase 1 (platelet)
IDBP-386828
thromboxane A synthase 1 (platelet)
IDBP-386829
thromboxane A synthase 1 (platelet)
IDBP-386831
thromboxane A synthase 1 (platelet)
IDBP-386832
thromboxane A synthase 1 (platelet)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to thromboxane A2, a potent vasoconstrictor and inducer of platelet aggregation. The enzyme plays a role in several pathophysiological processes including hemostasis, cardiovascular disease, and stroke. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:139777051-140020325
Strand Forward strand
Band q34
Transcripts
ENST00000336425 ENSP00000338087
ENST00000263552 ENSP00000263552
ENST00000425687 ENSP00000388736
ENST00000438104 ENSP00000388612
ENST00000416849 ENSP00000389414
ENST00000414508 ENSP00000392702
ENST00000448866 ENSP00000402536
ENST00000422328 ENSP00000415892
ENST00000458722 ENSP00000411274
ENST00000455353 ENSP00000391567
ENST00000411653 ENSP00000411326
ENST00000414041 ENSP00000412710
ENST00000493340
ENST00000462053
ENST00000474763
ENST00000481440
ENST00000473948
ENST00000492560
ENST00000476637
ENST00000462275
ENST00000469630
ENST00000494876
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004497 monooxygenase activity
GO:0004796 thromboxane-A synthase activity
GO:0005506 iron ion binding
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding
Biological Process
GO:0006690 icosanoid metabolic process
GO:0006805 xenobiotic metabolic process
GO:0019369 arachidonic acid metabolic process
GO:0019371 cyclooxygenase pathway
GO:0030644 cellular chloride ion homeostasis
GO:0044281 small molecule metabolic process
GO:0045907 positive regulation of vasoconstriction
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029925
View Gene Order
ENSBTAG00000020225
Not yet available
Pathways
NETPATH
REACTOME
REACT_150149
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) pathway
REACT_147851
Arachidonic acid metabolism pathway
REACT_13645
Eicosanoids pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_13567
Cytochrome P450 - arranged by substrate type pathway
REACT_111217
Metabolism pathway
REACT_13433
Biological oxidations pathway
REACT_13705
Phase 1 - Functionalization of compounds pathway
KEGG
hsa00590
Arachidonic acid metabolism pathway
INOH
INOH website
Prostaglandin Leukotriene metabolism pathway
PID NCI
Cross-References
SwissProt P24557
TrEMBL B7Z6W1 C9JS68 E7EP75 F8WC80 F8WD37 Q53F23
UniProt Splice Variant
Entrez Gene 6916
UniGene Hs.520757 Hs.724034
RefSeq NM_001061 NM_001130966 NM_001166253 NM_001166254 NM_030984
HUGO HGNC:11609
OMIM 274180
CCDS CCDS55174 CCDS55175 CCDS5855 CCDS5856
HPRD
IMGT
EMBL AC004914 AC004961 AC006021 AF233615 AF233616 AF233617 AF233618 AF233619 AF233620 AF233621 AF233622 AF233623 AF233624 AF233625 AK223466 AK296069 AK301049 BC014117 BC041157 CH471070 D34625 L36075 L36076 L36077 L36078 L36079 L36080 L36081 L36082 L36083 L36084 L36085 M74055 M80646 M80647
GenPept AAA36742 AAA60617 AAA60618 AAC01761 AAF99269 AAF99270 AAF99271 AAF99272 AAF99273 AAF99274 AAF99275 AAF99276 AAF99277 AAF99278 AAF99279 AAH14117 AAH41157 BAA07011 BAD97186 BAG58828 BAH13397 EAW83934 EAW83935
RNA Seq Atlas 6916

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca