Version 5.4
Homo sapiens Gene: GABRG3
Summary
InnateDB Gene IDBG-4418.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GABRG3
Gene Name gamma-aminobutyric acid (GABA) A receptor, gamma 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000182256
Encoded Proteins
IDBP-4420
gamma-aminobutyric acid (GABA) A receptor, gamma 3
IDBP-362262
gamma-aminobutyric acid (GABA) A receptor, gamma 3
IDBP-599515
gamma-aminobutyric acid (GABA) A receptor, gamma 3
IDBP-591851
gamma-aminobutyric acid (GABA) A receptor, gamma 3
IDBP-592391
gamma-aminobutyric acid (GABA) A receptor, gamma 3
IDBP-812455
gamma-aminobutyric acid (GABA) A receptor, gamma 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. The protein encoded by this gene is a gamma subunit, which contains the benzodiazepine binding site. Two transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Aug 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:26971282-27541991
Strand Forward strand
Band q12
Transcripts
ENST00000333743 ENSP00000331912
ENST00000451330 ENSP00000390708
ENST00000555083 ENSP00000452244
ENST00000553440
ENST00000554786
ENST00000554696 ENSP00000451862
ENST00000557596 ENSP00000450976
ENST00000615808 ENSP00000479113
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004890 GABA-A receptor activity
GO:0005230 extracellular ligand-gated ion channel activity
GO:0005254 chloride channel activity
Biological Process
GO:0006810 transport
GO:0006811 ion transport
GO:0007214 gamma-aminobutyric acid signaling pathway
GO:0007268 synaptic transmission
GO:0034220 ion transmembrane transport
GO:0042493 response to drug
GO:0055085 transmembrane transport
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0034707 chloride channel complex
GO:0045211 postsynaptic membrane
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000055026
View Gene Order
Pathways
NETPATH
REACTOME
REACT_25387
Ligand-gated ion channel transport pathway
REACT_24987
GABA A receptor activation pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_13685
Neuronal System pathway
REACT_25199
GABA receptor activation pathway
REACT_267716
Orphan transporters pathway
REACT_25300
Ion channel transport pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_15370
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL H0YJP1
UniProt Splice Variant
Entrez Gene 2567
UniGene Hs.569475 Hs.740015
RefSeq NM_001270873 NM_033223
HUGO HGNC:4088
OMIM 600233
CCDS CCDS45195 CCDS59251
HPRD 02579
IMGT
EMBL AC104002 AC127511 AC135326 AC136896 AC144833 AC145436 EU606049
GenPept
RNA Seq Atlas 2567

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca