InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GAPDHS

Summary

InnateDB Gene

IDBG-44465.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GAPDHS

Gene Name

glyceraldehyde-3-phosphate dehydrogenase, spermatogenic

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000105679

Encoded Proteins

IDBP-44467

glyceraldehyde-3-phosphate dehydrogenase, spermatogenic

IDBP-764229

IDBP-763354

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a protein belonging to the glyceraldehyde-3-phosphate dehydrogenase family of enzymes that play an important role in carbohydrate metabolism. Like its somatic cell counterpart, this sperm-specific enzyme functions in a nicotinamide adenine dinucleotide-dependent manner to remove hydrogen and add phosphate to glyceraldehyde 3-phosphate to form 1,3-diphosphoglycerate. During spermiogenesis, this enzyme may play an important role in regulating the switch between different energy-producing pathways, and it is required for sperm motility and male fertility. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:35533412-35545316

Strand

Forward strand

Band

q13.12

Transcripts

ENST00000222286	ENSP00000222286
ENST00000585510	ENSP00000467255
ENST00000586334	ENSP00000466432

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004365	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GO:0005515	protein binding
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0050661	NADP binding
GO:0051287	NAD binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006006	glucose metabolic process
GO:0006094	gluconeogenesis
GO:0006096	glycolytic process
GO:0030317	sperm motility
GO:0044281	small molecule metabolic process
GO:0045821	positive regulation of glycolytic process
GO:0055114	oxidation-reduction process