InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SAP30

Summary

InnateDB Gene

IDBG-44690.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SAP30

Gene Name

Sin3A-associated protein, 30kDa

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000164105

Encoded Proteins

IDBP-44692

Sin3A-associated protein, 30kDa

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP18, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This complex is active in deacetylating core histone octamers, but inactive in deacetylating nucleosomal histones. A pseudogene of this gene is located on chromosome 3. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:173369969-173377532

Strand

Forward strand

Band

q34.1

Transcripts

ENST00000296504	ENSP00000296504
ENST00000504618

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 54 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	54 [view]
Protein-Protein	49 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0035914	skeletal muscle cell differentiation